Synthesis of novel, chiral, water-soluble isothiazole derivatives

被引：3

作者：

Ciez, Dariusz ^{[1
]}

Szneler, Edward

机构：

[1] Jagiellonian Univ, Dept Organ Chem, PL-30060 Krakow, Poland

[2] Jagiellonian Univ, Fac Chem, NMR Lab, PL-30060 Krakow, Poland

来源：

JOURNAL OF CHEMICAL RESEARCH-S | 2007年 / 04期

关键词：

isothiazoles; chirality; unsaturated thioamides; oxidation; water solubility;

D O I：

10.3184/030823407X203396

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This article describes an easy preparation of some optically active, water soluble N-5,2,3,4-tetrasubstituted isothiazol5(2H)-imine hydrobromides from modified L-alpha-amino acids. lsothiazole rings are created in two-step reactions by oxidation of chiral 3-amino-2,3-unsaturated thioamides.

引用

页码：200 / 202

页数：3

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