Simple microwave-assisted method for the synthesis of primary thioamides from nitriles

被引：39

作者：

Bagley, MC ^{[1
]}

Chapaneri, K ^{[1
]}

Glover, C ^{[1
]}

Merritt, EA ^{[1
]}

机构：

[1] Cardiff Univ, Cardiff Sch Chem, Cardiff CF10 3TB, S Glam, Wales

来源：

SYNLETT | 2004年 / 14期

关键词：

thioamides; nitriles; microwaves;

D O I：

10.1055/s-2004-834812

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Primary thioamides are prepared in excellent yield from the corresponding nitrile by treatment with ammonium sulfide in methanol. at room temperature for electron-deficient aromatic nitriles or under microwave irradiation at 80 degreesC or 130 degreesC in 15-30 minutes for other aromatic and aliphatic nitriles. This procedure avoids the use of gaseous H,S under high pressure, proceeds in the absence of base and provides thioamides usually without the need for chromatographic purification.

引用

页码：2615 / 2617

页数：3

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