Aurora kinases A and B and familial breast cancer risk

被引：47
|
作者：
Tchatchou, Sandrine [1 ]
Wirtenberger, Michael
Hemminki, Kari
Sutter, Christian
Meindl, Alfons
Wappenschmidt, Barbara
Kiechle, Marion
Bugert, Peter
Schmutzler, Rita K.
Bartram, Claus R.
Burwinkel, Barbara
机构：
[1] German Canc Res Ctr, Div Mol Genet Epidemiol, D-6900 Heidelberg, Germany
[2] Karolinska Inst, Novum, Dept Biosci, Huddinge, Sweden
[3] Heidelberg Univ, Inst Human Genet, Heidelberg, Germany
[4] Tech Univ Munich, Klinikum Rechts Isar, Dept Obstet & Gynaecol, D-8000 Munich, Germany
[5] Univ Cologne, Div Mol Gynaeco Oncol, Dept Obstet & Gynaecol, Ctr Clin, Cologne, Germany
[6] Univ Hosp Cologne, Ctr Mol Med Cologne, Cologne, Germany
[7] Heidelberg Univ, Fac Clin Med, Inst Transfus Med & Immunol, Red Cross Blood Serv Baden Wurttemberg Hessia, D-6800 Mannheim, Germany
[8] Helmholtz Univ, Grp Mol Epidemiol, German Canc Res Ctr, Heidelberg, Germany
来源：
CANCER LETTERS | 2007年 / 247卷 / 02期
关键词：
breast cancer; case-control study; aurora kinases; polymorphism;
D O I：
10.1016/j.canlet.2006.05.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aurora genes play a crucial role in tumourigenesis and are overexpressed in many kinds of cancers. We investigated whether coding variants within the Aurora genes are associated with familial breast cancer risk. While AURKA Phe31Ile (1712T > A) and AURKB Thr298Met (893G > A) showed no association, the synonymous AURKB Ser295Ser (885A > G) polymorphism resulted in an increased breast cancer risk for carriers of the homozygous 885G genotype (OR = 1.45, 95% CI = 1.05-2.0, P = 0.02). Due to the impact of aurora kinases in the loss of chromosomal integrity during carcinogenesis, this variant may also influence the therapy outcome in breast cancer. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：266 / 272
页数：7
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