Antithrombotic Activity of a New Benzimidazole Derivative in the Thrombosis Model in Mice

被引：3
|
作者：
Smirnov, A. V. [1 ]
Kucheryavenko, A. F. [2 ]
Spasov, A. A. [2 ]
机构：
[1] Volgograd State Med Univ, Dept Pathol Anat, Volgograd, Russia
[2] Volgograd State Med Univ, Dept Pharmacol, Volgograd, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 05期
关键词：
antithrombotic activity; thrombosis; platelet aggregation; RU-891; acetylsalicylic acid; IN-VIVO; MOUSE;
D O I：
10.1007/s10517-014-2620-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Antithrombotic activity of a new benzimidazole derivative RU-891, characterized by antiaggregant activity, vs. reference drug acetylsalicylic acid was studied on the epinephrinecollagen thrombosis model in mice. Antithrombotic activity of RU-891 3-fold surpassed that of the reference drug. Histological studies showed that RU-891 significantly reduced the relative and mean areas of thrombi in sections of mouse lungs in comparison with the control.
引用
收藏
页码：580 / 582
页数：3
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