Regional changes in thalamic shape and volume are related to cognitive performance in multiple sclerosis

被引：29
|
作者：
Bisecco, Alvino [2 ,3 ]
Capuano, Rocco [2 ]
Caiazzo, Giuseppina [2 ,3 ]
d'Ambrosio, Alessandro [2 ,3 ]
Docimo, Renato [2 ]
Cirillo, Mario [2 ,3 ]
Russo, Antonio [2 ,3 ]
Altieri, Manuela [2 ,4 ]
Bonavita, Simona [2 ,3 ]
Rocca, Maria A. [5 ,6 ]
Filippi, Massimo [5 ,6 ]
Tedeschi, Gioacchino [2 ,3 ]
Gallo, Antonio [1 ,2 ,3 ]
机构：
[1] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Div Neurol 1, Piazza Miraglia 2, I-80138 Naples, Italy
[2] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy
[3] Univ Campania Luigi Vanvitelli, MRI Res Ctr, Naples, Italy
[4] Univ Campania Luigi Vanvitelli, Dept Psychol, Caserta, Italy
[5] IRCCS San Raffaele Sci Inst, Div Neurosci, Neurol Unit, Milan, Italy
[6] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Dept Neurol, Neuroimaging Res Unit,Inst Expt Neurol,Div Neuros, Milan, Italy
来源：
MULTIPLE SCLEROSIS JOURNAL | 2021年 / 27卷 / 01期
关键词：
Multiple sclerosis; thalamus; vertex analysis; cognition; magnetic resonance imaging; atrophy; PROCESSING SPEED; ATROPHY;
D O I：
10.1177/1352458519892552
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: The relationship between cognitive performance and regional thalamic atrophy in multiple sclerosis (MS) has been investigated in recent studies. Objective and methods: To further assess this relationship, 118 relapsing-remitting MS patients and 52 healthy controls underwent a neuropsychological assessment and a 3T-MRI (3-Tesla magnetic resonance imaging). Cognitive performances were correlated with thalamic shape changes by using Vertex Analysis. Results: Information processing speed performance correlated with atrophy of frontal/motor-connected thalamic sub-regions. Inhibitory control performance correlated with atrophy of all thalamic sub-regions. Global cognitive status correlated with atrophy of frontal/temporal-connected sub-regions. Conclusions: These findings support the hypothesis that, within the thalamus, the damage of the anterior regions is most relevant for cognitive dysfunction.
引用
收藏
页码：134 / 138
页数：5
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