Actin' between phase separated domains for heterochromatin repair

被引：14
|
作者：
Rawal, Chetan C. [1 ]
Caridi, Christopher P. [1 ]
Chiolo, Irene [1 ]
机构：
[1] Univ Southern Calif, Mol & Computat Biol Dept, Los Angeles, CA 90089 USA
来源：
DNA REPAIR | 2019年 / 81卷
关键词：
Homologous recombination; Nuclear actin filaments; Heterochromatin; Phase separation; DSB repair; DOUBLE-STRAND BREAK; DNA-DAMAGE RESPONSE; UBIQUITIN E3 LIGASE; HOMOLOGOUS RECOMBINATION; NUCLEAR ACTIN; SATELLITE REPEATS; ANALYSIS REVEALS; DYNAMICS; PROTEIN; GENOME;
D O I：
10.1016/j.dnarep.2019.102646
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
DNA double-strand breaks (DSBs) are particularly challenging to repair in pericentromeric heterochromatin because of the increased risk of aberrant recombination in highly repetitive sequences. Recent studies have identified specialized mechanisms enabling 'safe' homologous recombination (HR) repair in heterochromatin. These include striking nuclear actin filaments (F-actin) and myosins that drive the directed motion of repair sites to the nuclear periphery for 'safe' repair. Here, we summarize our current understanding of the mechanisms involved, and propose how they might operate in the context of a phase-separated environment.
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页数：11
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