Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase (vol 59, pg 6281, 2016)

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作者
Degorce, Sebastien L.
Barlaam, Bernard
Cadogan, Elaine
Dishington, Allan
Ducray, Richard
Glossop, Steven C.
Hassall, Lorraine A.
Lach, Franck
Lau, Alan
McGuire, Thomas M.
Nowak, Thorsten
Ouvry, Gilles
Pike, Kurt G.
Thomason, Andrew G.
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D O I
10.1021/acs.jmedchem.8b00936
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R914 [药物化学];
学科分类号
100701 ;
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页码:6398 / 6398
页数:1
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  • [1] Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase
    Degorce, Sebastien L.
    Barlaam, Bernard
    Cadogan, Elaine
    Dishington, Allan
    Ducray, Richard
    Glossop, Steven C.
    Hassall, Lorraine A.
    Lach, Franck
    Lau, Alan
    McGuire, Thomas M.
    Nowak, Thorsten
    Ouvry, Gilles
    Pike, Kurt G.
    Thomason, Andrew G.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (13) : 6281 - 6292
  • [2] Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors
    Barlaam, Bernard
    Cadogan, Elaine
    Campbell, Andrew
    Colclough, Nicola
    Dishington, Allan
    Durant, Stephen
    Goldberg, Kristin
    Hassall, Lorraine A.
    Hughes, Gareth D.
    MacFaul, Philip A.
    McGuire, Thomas M.
    Pass, Martin
    Patel, Anil
    Pearson, Stuart
    Petersen, Jens
    Pike, Kurt G.
    Robb, Graeme
    Stratton, Natalie
    Xin, Guohong
    Zhai, Baochang
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2018, 9 (08): : 809 - 814
  • [3] Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors
    Leahy, James W.
    Buhr, Chris A.
    Johnson, Henry W. B.
    Kim, Byung Gyu
    Baik, TaeGon
    Cannoy, Jonah
    Forsyth, Timothy P.
    Jeong, Joon Won
    Lee, Matthew S.
    Ma, Sunghoon
    Noson, Kevin
    Wang, Longcheng
    Williams, Matthew
    Nuss, John M.
    Brooks, Eric
    Foster, Paul
    Goon, Leanne
    Heald, Nathan
    Holst, Charles
    Jaeger, Christopher
    Lam, Scott
    Lougheed, Julie
    Lam Nguyen
    Plonowski, Arthur
    Song, Joanne
    Stout, Thomas
    Wu, Xiang
    Yakes, Michael F.
    Yu, Peiwen
    Zhang, Wentao
    Lamb, Peter
    Raeber, Olivia
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (11) : 5467 - 5482
  • [4] Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents
    Charrier, Jean-Damien
    Durrant, Steven J.
    Golec, Julian M. C.
    Kay, David P.
    Knegtel, Ronald M. A.
    MacCormick, Somhairle
    Mortimore, Michael
    O'Donnell, Michael E.
    Pinder, Joanne L.
    Reaper, Philip M.
    Rutherford, Alistair P.
    Wang, Paul S. H.
    Young, Stephen C.
    Pollard, John R.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (07) : 2320 - 2330
  • [5] Discovery of potent and selective inhibitors of Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents
    Charrier, Jean-Damien
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [6] Discovery of Thieno[3,2-d]pyrimidine derivatives as potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) kinase
    Duan, Yunxin
    Cheng, Haodong
    Zhuang, Lili
    Xia, Jiawei
    Xu, Yerong
    Zhang, Ruyue
    Sun, Rui
    Lu, Tao
    Chen, Yadong
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 255
  • [7] Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554 (vol 19, pg 4482, 2011)
    Maezaki, Hironobu
    Banno, Yoshihiro
    Miyamoto, Yasufumi
    Moritoh, Yusuke
    Asakawa, Tomoko
    Kataoka, Osamu
    Takeuchi, Koji
    Suzuki, Nobuhiro
    Ikedo, Koji
    Kosaka, Takuo
    Sasaki, Masako
    Tsubotani, Shigetoshi
    Tani, Akiyoshi
    Funami, Miyuki
    Yamamoto, Yoshio
    Tawada, Michiko
    Aertgeerts, Kathleen
    Yano, Jason
    Oi, Satoru
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (18) : 5742 - 5742
  • [8] The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer
    Lewis, Richard T.
    Bode, Christiane M.
    Choquette, Deborah M.
    Potashman, Michele
    Romero, Karina
    Stellwagen, John C.
    Teffera, Yohannes
    Moore, Earl
    Whittington, Douglas A.
    Chen, Hao
    Epstein, Linda F.
    Emkey, Renee
    Andrews, Paul S.
    Yu, Violeta L.
    Saffran, Douglas C.
    Xu, Man
    Drew, Allison
    Merkel, Patricia
    Szilvassy, Steven
    Brake, Rachael L.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (14) : 6523 - 6540
  • [9] Discovery and optimization of quinazolinone-pyrrolo-dihydropyrrolones as potent, selective, and orally bioavailable Pim1,2,3 kinase inhibitors
    Pettus, Liping
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
  • [10] Discovery of [1,2,3]Triazolo[4,5-c]quinoline Derivatives as a New Class of Ataxia-Telangiectasia Mutated Kinase Inhibitors
    Zhang, Shiyu
    Zhou, Pei
    Liu, Jingming
    Xia, Anjie
    Lin, Guifeng
    Xiang, Zhiyu
    Fang, Zhen
    Yang, Xin
    Qiao, Jingxin
    Hu, Qian
    Zhang, Jiahao
    Zhao, Jinlong
    Li, Linli
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2023, 14 (06): : 746 - 756