Hypoxic-Ischemic Encephalopathy in the Term Infant

被引：202

作者：

Fatemi, All ^{[1
]}

Wilson, Mary Ann ^{[1
]}

Johnston, Michael V. ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Neurol, Kennedy Krieger Inst, Baltimore, MD 21205 USA

来源：

CLINICS IN PERINATOLOGY | 2009年 / 36卷 / 04期

关键词：

Hypoxia-ischemia; Neonatal encephalopathy; Apoptosis; Oxidative stress; Hypothermia; PERINATAL BRAIN-INJURY; NITRIC-OXIDE SYNTHASE; APOPTOSIS-INDUCING FACTOR; METHYL-D-ASPARTATE; OXYGEN-GLUCOSE DEPRIVATION; NF-KAPPA-B; FOCAL CEREBRAL-ISCHEMIA; FREE-RADICAL PRODUCTION; NEURONAL CELL-DEATH; NEONATAL-RAT BRAIN;

D O I：

10.1016/j.clp.2009.07.011

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and associated disabilities in children. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades, and many new molecular mechanisms have been identified. Despite all these advances, therapeutic interventions are still limited. In this article the authors discuss several molecular pathways involved in hypoxia-ischemia, and potential therapeutic targets.

引用

页码：835 / +

页数：25

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