Hypoxic-Ischemic Encephalopathy in the Term Infant

被引：202
|
作者：
Fatemi, All [1 ]
Wilson, Mary Ann [1 ]
Johnston, Michael V. [1 ]
机构：
[1] Johns Hopkins Med Inst, Dept Neurol, Kennedy Krieger Inst, Baltimore, MD 21205 USA
来源：
CLINICS IN PERINATOLOGY | 2009年 / 36卷 / 04期
关键词：
Hypoxia-ischemia; Neonatal encephalopathy; Apoptosis; Oxidative stress; Hypothermia; PERINATAL BRAIN-INJURY; NITRIC-OXIDE SYNTHASE; APOPTOSIS-INDUCING FACTOR; METHYL-D-ASPARTATE; OXYGEN-GLUCOSE DEPRIVATION; NF-KAPPA-B; FOCAL CEREBRAL-ISCHEMIA; FREE-RADICAL PRODUCTION; NEURONAL CELL-DEATH; NEONATAL-RAT BRAIN;
D O I：
10.1016/j.clp.2009.07.011
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and associated disabilities in children. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades, and many new molecular mechanisms have been identified. Despite all these advances, therapeutic interventions are still limited. In this article the authors discuss several molecular pathways involved in hypoxia-ischemia, and potential therapeutic targets.
引用
收藏
页码：835 / +
页数：25
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