Quantitative assessment of the association between Fas/FasL gene polymorphism and susceptibility to esophageal carcinoma in a north Chinese population

被引:3
|
作者
Zhang, Meijuan [1 ]
Wu, Cuiping [1 ]
Li, Baohuan [1 ]
Du, Wenjun [1 ]
Zhang, Chuanzhen [1 ]
Chen, Ziping [1 ]
机构
[1] Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Gastroenterol, Jinan 250100, Peoples R China
来源
CANCER MEDICINE | 2016年 / 5卷 / 04期
关键词
Esophageal carcinoma; Fas; FasL; polymorphism; SQUAMOUS-CELL CARCINOMA; FAS LIGAND EXPRESSION; BREAST-CANCER; LUNG-CANCER; CERVICAL CARCINOGENESIS; MOLECULAR-CLONING; APO-1/CD95; GENE; SURFACE ANTIGEN; RISK; PROMOTER;
D O I
10.1002/cam4.633
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The case-control study aims to investigate the association of Fas and FasL genetic polymorphisms (Fas-670A/G (rs1800682), Fas-1377G/A (rs2234767) and FasL-844T/C (rs763110)) with esophageal carcinoma susceptibility in a north Chinese population. A total of 204 patients with esophageal carcinoma and 248 healthy controls were enrolled from Henan, China and genotyped by the polymerase chain reaction and restriction fragment length polymorphism method. There were no significant differences in distributions of their genotypes frequencies between patients and controls in Fas-670A/G, Fas-1377G/A and FasL-844T/C polymorphisms (P>0.05). Stratified analysis showed that no significant association was found between esophageal carcinoma and gene polymorphisms of Fas-670 A/G, Fas-1377G/A, and FasL-844T/C (P>0.05). Genetic polymorphisms in the death pathway genes Fas and FasL were not associated with risk of developing esophageal carcinoma in a north Chinese population.
引用
收藏
页码:760 / 766
页数:7
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