Mosquitocidal efficacy of embelin and its derivatives against Aedes aegypti L. and Culex quinquefasciatus Say. (Diptera: Culicidae) and computational analysis of acetylcholinesterase 1 (AChE1) inhibition

被引：6

作者：

Stalin, Antony ^{[1
]}

Reegan, Appadurai Daniel ^{[2
,7
]}

Gandhi, Munusamy Rajiv ^{[3
]}

Saravanan, R. R. ^{[4
]}

Balakrishna, Kedike ^{[5
]}

Hesham, Abd El-Latif ^{[6
]}

Ignacimuthu, Savarimuthu ^{[7
]}

Zhang, Ying ^{[8
]}

机构：

[1] Univ Elect Sci & Technol China, Inst Fundamental & Frontier Sci, Chengdu 610054, Peoples R China

[2] Natl Ctr Dis Control, Bengaluru Branch, 8 NTI Campus,Bellary Rd, Bengaluru 560003, Karnataka, India

[3] Natl Biodivers Author, 5th Floor,CSIR Rd,TICEL Bio Pk, Chennai 600113, Tamil Nadu, India

[4] Meenakshi Chandrasekaran Coll Arts & Sci, Dept Phys, Pattukkottai 614626, Thanjavur, India

[5] Univ Madras, Loyola Coll, Entomol Res Inst, Chennai 600034, Tamil Nadu, India

[6] Beni Suef Univ, Fac Agr, Genet Dept, Bani Suwayf 62511, Egypt

[7] Manonmaniam Sundaranar Univ, Xavier Res Fdn, St Xaviers Coll, Palayankottai 627002, Tamil Nadu, India

[8] Southwest Med Univ, Dept Anesthesiol, Hosp TCM, Luzhou, Peoples R China

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 2022年 / 146卷

基金：

中国国家自然科学基金;

关键词：

Embelin; Derivatives; Mosquitocidal efficacy; Molecular docking; Molecular dynamics; Aedes aegypti; Culex quinquefasciatus; IN-VITRO; PYRETHROIDS; NILOTICIN; VILANGIN; MODE;

D O I：

10.1016/j.compbiomed.2022.105535

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Embelin was isolated from the chloroform extract of Embelia ribes (Burm.f.) fruits; its derivative compounds 6bromoembelin and vilangin were prepared, and they were evaluated for mosquitocidal activities against the third instar larvae and pupae of Aedes aegypti L. and Culex quinquefasciatus Say. (Diptera: Culicidae). The concentrations used were 0.5, 1.0, 1.5, and 2.0 ppm. Embelin recorded LC50 values of 5.79 and 5.54 ppm against the larvae of Ae. aegypti and Cx. quinquefasciatus, respectively. Similarly, the LC50 values of embelin were 10.23 and 6.93 ppm against the pupae of Ae. aegypti and Cx. quinquefasciatus, respectively. Of the two derivatives tested, vilangin showed the highest larvicidal activity with LC50 values of 1.38 and 1.28 ppm against the larvae of Ae. aegypti and Cx. quinquefasciatus, respectively. Similarly, the LC50 values of vilangin were 1.60 and 1.43 ppm against the pupae of Ae. aegypti and Cx. quinquefasciatus, respectively. The LC50 values of 6-bromoembelin were 3.30 and 2.83 ppm against the larvae and 4.40 and 4.30 ppm against the pupae of Ae. aegypti and Cx. quinquefasciatus, respectively. The histopathological results displayed significant damage on cuboidal cells of the midgut (CU) in vilangin treated larvae of Ae. aegypti and Cx. quinquefasciatus at a concentration of 2.0 ppm. Similarly, peritrophic membrane (PM) was completely impaired in vilangin-treated larvae of Cx. quinquefasciatus and midgut content (MC) was very low in vilangin-treated larvae of Cx. quinquefasciatus. In addition, molecular docking and molecular dynamics studies demonstrated the efficacy of vilangin on the inhibition of acetylcholinesterase (AChE1) in Ae. aegypti and Cx. quinquefasciatus. The present results suggest that vilangin could be used to develop a natural active product against mosquito larvae.

引用

页数：15

共 40 条

[31] Ovicidal and adulticidal potential of leaf and seed extract of Albizia lebbeck (L.) Benth. (Family: Fabaceae) against Culex quinquefasciatus, Aedes aegypti, and Anopheles stephensi (Diptera: Culicidae)
Marimuthu Govindarajan
Mohan Rajeswary
[J]. Parasitology Research, 2015, 114 : 1949 - 1961
[32] Ovicidal and adulticidal potential of leaf and seed extract of Albizia lebbeck (L.) Benth. (Family: Fabaceae) against Culex quinquefasciatus, Aedes aegypti, and Anopheles stephensi (Diptera: Culicidae)
Govindarajan, Marimuthu
Rajeswary, Mohan
[J]. PARASITOLOGY RESEARCH, 2015, 114 (05) : 1949 - 1961
[33] Occurrence of Apocrine Secretion in the Larval Gut Epithelial Cells of Aedes aegypti L., Anopheles albitarsis Lynch-Arribalzaga and Culex quinquefasciatus Say (Diptera: Culicidae): a Defense Strategy Against Infection by Bacillus sphaericus Neide?
Oliveira, Caroline D.
Tadei, Wanderli P.
Abdalla, Fabio C.
[J]. NEOTROPICAL ENTOMOLOGY, 2009, 38 (05) : 624 - 631
[34] Larvicidal activity of Argel (Solenostemma argel Del Hyne) and Prickly Poppy (Argemone mexicana L.) Acetone Extracts against Mosquito Larvae of Culex quinquefasciatus (Say.) and Anopheles arabiensis (Diptera: Culicidae)
Elawad, L. M. E.
Eweis, E. A.
Abou-Bakr, H.
[J]. EGYPTIAN JOURNAL OF BIOLOGICAL PEST CONTROL, 2014, 24 (01) : 259 - 264
[35] Studies on the Phytochemical Profile of Ocimum basilicum var. minimum (L.) Alef. Essential Oil, Its Larvicidal Activity and In Silico Interaction with Acetylcholinesterase against Aedes aegypti (Diptera: Culicidae)
Botelho, Anderson de Santana
Ferreira, Oberdan Oliveira
de Oliveira, Mozaniel Santana
Cruz, Jorddy Neves
dos Reis Chaves, Sandro Henrique
do Prado, Alejandro Ferraz
do Nascimento, Lidiane Diniz
da Silva, Geilson Alcantara
do Amarante, Cristine Bastos
de Aguiar Andrade, Eloisa Helena
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (19)
[36] Isolation of limonoid compound (Hamisonine) from endophytic fungi Penicillium oxalicum LA-1 (KX622790) of Limonia acidissima L. for its larvicidal efficacy against LF vector, Culex quinquefasciatus (Diptera: Culicidae)
Seetharaman, Prabukumar
Gnanasekar, Sathishkumar
Chandrasekaran, Rajkuberan
Chandrakasan, Gobinath
Syed, Asad
Hodhod, Mohamed S.
Ameen, Fuad
Sivaperumal, Sivaramakrishnan
[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2017, 24 (26) : 21272 - 21282
[37] Isolation of limonoid compound (Hamisonine) from endophytic fungi Penicillium oxalicum LA-1 (KX622790) of Limonia acidissima L. for its larvicidal efficacy against LF vector, Culex quinquefasciatus (Diptera: Culicidae)
Prabukumar Seetharaman
Sathishkumar Gnanasekar
Rajkuberan Chandrasekaran
Gobinath Chandrakasan
Asad Syed
Mohamed S. Hodhod
Fuad Ameen
Sivaramakrishnan Sivaperumal
[J]. Environmental Science and Pollution Research, 2017, 24 : 21272 - 21282
[38] Cyt1Ab1 and Cyt2Ba1 from Bacillus thuringiensis subsp medellin and B-thuringiensis subsp israelensis synergize Bacillus sphaericus against Aedes aegypti and resistant Culex quinquefasciatus (Diptera: Culicidae)
Wirth, MC
Delécluse, A
Walton, WE
[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2001, 67 (07) : 3280 - 3284
[39] Efficacy of essential oil from Cananga odorata (Lamk.) Hook.f. & Thomson (Annonaceae) against three mosquito species Aedes aegypti (L.), Anopheles dirus (Peyton and Harrison), and Culex quinquefasciatus (Say)
Mayura Soonwera
[J]. Parasitology Research, 2015, 114 : 4531 - 4543
[40] Efficacy of essential oil from Cananga odorata (Lamk.) Hook.f. & Thomson (Annonaceae) against three mosquito species Aedes aegypti (L.), Anopheles dirus (Peyton and Harrison), and Culex quinquefasciatus (Say)
Soonwera, Mayura
[J]. PARASITOLOGY RESEARCH, 2015, 114 (12) : 4531 - 4543

← 1 2 3 4 →