Chemical Constituents of Alnus firma and Their Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglia

被引：26
|
作者：
Lee, Min A. [1 ,2 ]
Lee, Hee Kyoung [3 ]
Kim, Seung Hyun [3 ]
Kim, Young Choong [1 ,2 ]
Sung, Sang Hyun [1 ,2 ]
机构：
[1] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea
[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
[3] ElcomSci Co Ltd, Inst Life Sci, Seoul, South Korea
来源：
PLANTA MEDICA | 2010年 / 76卷 / 10期
关键词：
Alnus firma (Betulaceae); phenolic glycosides; diarylheptanoids; nitric oxide; BV2; microglia; lipopolysaccharide; DIARYLHEPTANOID GLYCOSIDES; BETULA-PENDULA; PHENOLIC-COMPOUNDS; IN-VITRO; JAPONICA; LEAVES; PLATYPHYLLOSIDE; DIGESTIBILITY; MECHANISMS; BIRCH;
D O I：
10.1055/s-0029-1240911
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A methanolic extract of Alnus firma barks (Betulaceae) significantly attenuated nitric oxide production in lipopolysaccharide-stimulated BV2 microglia. Two new compounds, characterized as 4-hydroxy-2,6-dimethoxyphenyl 6'-O-syringoyl-beta-D-glucopyranoside (1) and 4-hydroxy-2,6-dimethoxyphenyl 6'-O-vanilloyl-beta-D-glucopyranoside (2), were isolated from the barks of A. firma using bioactivity-guided fractionation, together with two known phenolic glycosides (3, 4) and 11 known diarylheptanoids (5-15). Among these compounds, 1-4 and 6-11 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 10 mu M to 100 mu M.
引用
收藏
页码：1007 / 1010
页数：4
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