Severe Infections in HIV-Exposed Uninfected Infants: Clinical Evidence of Immunodeficiency

被引：77
|
作者：
Slogrove, A. L. [1 ,2 ]
Cotton, M. F. [1 ,2 ]
Esser, M. M. [1 ,2 ]
机构：
[1] Tygerberg Childrens Hosp, ZA-7505 Tygerberg, Western Cape, South Africa
[2] Univ Stellenbosch, Dept Paediat & Child Hlth, ZA-7600 Stellenbosch, South Africa
来源：
JOURNAL OF TROPICAL PEDIATRICS | 2010年 / 56卷 / 02期
关键词：
HIV-exposed uninfected; infectious morbidity; immuneparesis; Pneumocystis jiroveci; TO-CHILD TRANSMISSION; VIRUS TYPE-1 INFECTION; PNEUMOCYSTIS-JIROVECI; CELL ACTIVITY; BORN; MORTALITY; MORBIDITY; VARICELLA; RESPONSES; ENVELOPE;
D O I：
10.1093/tropej/fmp057
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
We describe the clinical and basic immunological findings of eight HIV-exposed uninfected infants hospitalized with serious infectious morbidity and referred for immunological evaluation. The median age at presentation was 5.5 (1.5-15) months. Infections included Pneumocystis jiroveci pneumonia (three), cytomegalovirus colitis with perforation (one), Pseudomonas sepsis (two), hemorrhagic varicella (one) and Group A streptococcal meningitis and endocarditis (one). Five required intensive care, four for assisted ventilation and one for post-surgical care. Follow-up to 36 months suggested resolution of a transient immunodeficiency in two infants, one of whom had CD4 and the other B-cell depletion. Further studies are indicated in HIV-exposed uninfected infants.
引用
收藏
页码：75 / 81
页数：7
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