Association of the polymorphisms of the ERBB3 and SH2B3 genes with type 1 diabetes

被引：8
|
作者：
Nikitin, A. G. [1 ]
Lavrikova, E. Y. [1 ]
Seregin, Y. A. [1 ]
Zilberman, L. I. [2 ]
Tzitlidze, N. M. [2 ]
Kuraeva, T. L. [2 ]
Peterkova, V. A. [2 ]
Dedov, I. I. [2 ]
Nosikov, V. V. [1 ]
机构：
[1] State Res Ctr GosNIIgenetika, Moscow 117545, Russia
[2] Sci Ctr Endocrinol, Moscow 117036, Russia
来源：
MOLECULAR BIOLOGY | 2010年 / 44卷 / 02期
关键词：
type 1 diabetes mellitus; polymorphic markers rs2292239 of ERBB3 gene and rs3184504 of the SH2B3 gene; functional polymorphism Trp262Arg; GENOME-WIDE ASSOCIATION; 7 COMMON DISEASES; BLOOD-PRESSURE; LOCI; SUSCEPTIBILITY; VARIANTS; RISK; LOCALIZATION; METAANALYSIS; MELLITUS;
D O I：
10.1134/S002689331002007X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To study the association with diabetes mellitus type 1, we analyzed the distribution of allele and genotype frequencies of polymorphic marker rs2292239 of ERBB3 gene, encoding epidermal growth factor receptor type 3 and polymorphic marker rs3184504 of SH2B3 gene, encoding adaptor protein LNK. The study included groups of T1DM patients and unrelated controls of Russian origin. Genotyping was performed using RFLP and real-time amplification methods. No statistically significant association with type 1 diabetes was found for the polymorphic marker rs2292239 of ERBB3, while the analysis of the distribution of allele and genotype frequencies of the polymorphic marker rs3184504 of SH2B3 gene revealed the association with T1DM in the Russian population.
引用
收藏
页码：228 / 232
页数：5
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