Synthesis of new furo[2,3-d]pyrimidines and Pyrimido[4′,5′:4,5]furo[2,3-d]pyrimidines

被引：11

作者：

Moneam, MIA ^{[1
]}

Geies, AA ^{[1
]}

El-Naggar, GM ^{[1
]}

Mousa, SM ^{[1
]}

机构：

[1] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2004年 / 51卷 / 06期

关键词：

furopyrimidines; pyrimidofuropyrimidines; synthesis; biological activity;

D O I：

10.1002/jccs.200400198

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sodium salt of 4-hydroxy-6-methyl-2-phenylpyrimidine-5-carbonitrile (3) was subjected to alkylation with different alpha-halo compounds, where the corresponding O-alkylated products 4(a-g) were obtained. Ring closure of the O-alkylated product 4(a-c) performed using sodium ethoxide in refluxing ethanol afforded furo[2,3-d]-pyrimidines 5(a-c). The latter compounds on reaction with a variety of reagents gave other new furopyrimidines as well as a number of furodipyrimidines.

引用

页码：1357 / 1366

页数：10

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