Communication Between EphrinB2 and EphB4 Within the Osteoblast Lineage

被引：57

作者：

Martin, T. J. ^{[1
,2
]}

Allan, E. H. ^{[1
,2
]}

Ho, P. W. M. ^{[1
,2
]}

Gooi, J. H. ^{[1
,2
]}

Quinn, J. M. W. ^{[4
]}

Gillespie, M. T. ^{[3
]}

Krasnoperov, V. ^{[5
]}

Sims, N. A. ^{[1
,2
]}

机构：

[1] St Vincents Inst, Dept Med, Fitzroy, Vic 3065, Australia

[2] Univ Melbourne, Fitzroy, Vic 3065, Australia

[3] St Vincents Inst, Dept Med, Prince Henrys Inst, Clayton, Vic 3168, Australia

[4] Univ Melbourne, Prince Henrys Inst, Clayton, Vic 3168, Australia

[5] Vasgene Therapeut, Los Angeles, CA 90033 USA

来源：

OSTEOIMMUNOLOGY: INTERACTIONS OF THE IMMUNE AND SKELETAL SYSTEMS II | 2010年 / 658卷

关键词：

Osteoblast; Ephrins; PTHrP; Bone remodeling; BONE-FORMATION; GROWTH-FACTORS; RECEPTOR; REVERSE; CELL; OSTEOCLASTS; PTHRP; BETA;

D O I：

10.1007/978-1-4419-1050-9_6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity. Production of ephrinB2 mRNA and protein are increased by PTH and PTHrP in osteoblasts. Both a synthetic peptide antagonist of ephrinB2/EphB4 receptor interaction and recombinant soluble extracellular domain of EphB4 (sEphB4), which is an antagonist of both forward and reverse EphB4 signaling, were able to inhibit mineralization and the expression of several osteoblast genes involved late in osteoblast differentiation. The findings are consistent with ephrinB2/EphB4 signaling within the osteoblast lineage having a paracrine role in osteoblast differentiation, in addition to the proposed role of osteoclast-derived ephrinB2 in coupling of bone formation to resorption. This local regulation might contribute to control of osteoblast differentiation and bone formation at remodeling sites, and perhaps also in modeling.

引用

页码：51 / 60

页数：10

共 50 条

[21] The expressions of EphB4 and ephrinB2 in lung adenocarcinomas: a high level of the EphB4 protein is associated with lymph node metastasis
Li, Ji
Sung, Yuejun
Wang, Xiaoxia
Wang, Jiandong
Zhu, Yehang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2019, 12 (09): : 3447 - 3452
[22] Parathyroid Hormone Increases EphrinB2/EphB4 of Osteoclast/Osteoblast Coupling Factor in Primary Hyperparathyroidism Model.
Nagata, Yuki
Imanishi, Yasuo
Miyaoka, Daichi
Hayashi, Noriyuki
Maeda, Tomomi
Emoto, Masanori
Inaba, Masaaki
JOURNAL OF BONE AND MINERAL RESEARCH, 2017, 32 : S74 - S74
[23] 浅谈EphrinB2/ephB4在骨重建中的作用
吴梓齐
杨涛源
王景云
中华老年口腔医学杂志, 2014, 12 (03) : 184 - 187
[24] Ocular safety profile and intraocular pharmacokinetics of an antagonist of EphB4/EphrinB2 signalling
Brar, Manpreet
Cheng, Lingyun
Yuson, Ritchie
Mojana, Francesca
Freeman, William R.
Gill, Parkash S.
BRITISH JOURNAL OF OPHTHALMOLOGY, 2010, 94 (12) : 1668 - 1673
[25] Activation Of EphrinB2/EphB4 Influences Myeloid Leukemia Cell Migration and Invasion
Zhou, Xuan
Liu Xiaoli
Xiao, Yajuan
Zhang, Jinfang
Huang, Bintao
Du, Qingfeng
BLOOD, 2013, 122 (21)
[26] The EphB4/ephrinB2 signaling; a potential targeted therapy for myeloma bone disease
Pennisi, A.
Ling, W.
Li, X.
Khan, S.
Yaccoby, S.
BONE, 2010, 47 : S269 - S269
[27] Cell adhesion to ephrinb2 is induced by EphB4 independently of its kinase activity
Sakamoto, H
Zhang, XQ
Suenobu, S
Ohbo, K
Ogawa, M
Suda, T
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 321 (03) : 681 - 687
[28] EphrinB2/EphB4信号转导与肿瘤血管生成
余健
辛艳飞
由振强
宣尧仙
生命的化学, 2011, 31 (06) : 849 - 851
[29] Blockade of Ephrin/EphB4 Signaling within the Osteoblast Lineage Reduces Osteoblast Differentiation and Mineralization
Allan, E. H.
Pompolo, S.
Gooi, J. H.
Gillespie, M. T.
Sims, N. A.
Krasnoperov, V.
Martin, T. J.
JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 : S253 - S253
[30] Endothelial ephrinB2/EphB4 signaling controls permeability of glioma blood vessels
Erber, Ralf
Eichelsbacher, Uta
Powajbo, Violetta
Djonov, Valentin
Korn, Tobias
Ullrich, Axel
Vajkoczy, Peter
CANCER RESEARCH, 2006, 66 (08)

← 1 2 3 4 5 →