Rate enhancement by water in a TiCl4-mediated stereoselective vinylogous Mukaiyama aldol reaction

被引：33
|
作者：
Yamaoka, Makoto [1 ]
Nakazaki, Atsuo [1 ]
Kobayashi, Susumu [1 ]
机构：
[1] Tokyo Univ Sci RIKADAI, Fac Pharmaceut Sci, Noda, Chiba 2788510, Japan
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 02期
基金：
日本学术振兴会;
关键词：
Vinylogous Mukaiyama aldol reaction; Rate enhancement; Water; TiCl4-mediated reaction; DIELS-ALDER REACTION; 1ST TOTAL-SYNTHESIS; BIOACTIVE NATURAL-PRODUCTS; BRONSTED ACID; LEWIS-ACID; STRUCTURAL DETERMINATION; REVISED STRUCTURES; ACTINOPYRONE-A; BLA CATALYST; ALDEHYDES;
D O I：
10.1016/j.tetlet.2009.10.140
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A remarkable enhancement in the rate of a TiCl4-mediated stereoselective vinylogous Mukaiyama aldol reaction (VMAR) using vinylketene silyl N,O-acetal 1 was observed in the presence of water. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：287 / 289
页数：3
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