Protective Effects of Compounds in Bombax ceiba flower on Benzo[a]pyrene-Induced Cytotoxicity

被引：0

作者：

Nakashima, Souichi ^{[1
,2
]}

Oda, Yoshimi ^{[1
,2
]}

Ogawa, Yuki ^{[1
]}

Nakamura, Seikou ^{[1
]}

Uno, Miyako ^{[1
]}

Kishimoto, Mariko ^{[1
]}

Yoshikaw, Masayuki ^{[1
]}

Matsuda, Hisashi ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Dept Pharmacognosy, Yamashina Ku, Kyoto 6078412, Japan

[2] NTH Co Ltd, Shibuya Ku, 1-8-11 4F Sky Ebisu Bldg, Tokyo 1500013, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 05期

关键词：

Bombax ceiba; Benzo[a]pyrene; (-)-Loliolide; Cell protection; FLAVONOID GLYCOSIDES; PHENOLIC-COMPOUNDS; CONSTITUENTS; DERIVATIVES; LUPEOL; CELLS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanolic extract of the flower of Bombax ceiba was found to show protective effects on cytotoxicity induced by benzo[a]pyrene (BaP) in HT1080 cells. We therefore tried to examine and estimate the active constituents. We isolated 16 compounds from the extract, including four butyrolactones and two ascorbic acid derivatives, as well as mangiferin. Among the isolated compounds, a butyrolactone derivative, (-)-loliolide, and two flavonoids, kaempferol 3-O-beta-D-glucopyranoside and quercetin 3-O-beta-D-glucopyranoside, protected the cells against the BaP-induced cytotoxicity. Quercetin, the aglycone of one of the active constituents, showed a weaker effect than its glycoside. This is the first report of the protective effects of the methanolic extract of B. ceiba and its constituents on BaP-induced cytotoxicity.

引用

页码：561 / 564

页数：4

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