Cancer imaging: novel concepts in clinical magnetic resonance imaging

Kwee TC, Takahara T, Klomp DWJ, Luijten PR. (University Medical Center Utrecht, Utrecht, The Netherlands). Cancer imaging: novel concepts in clinical magnetic resonance imaging. J Intern Med 2010; 268: 120-132. Cancer is a major public health problem in the Western world. Imaging is of crucial importance in oncology, because it may reduce cancer-related morbidity and mortality. To improve tumour evaluation, there is a need for functional imaging modalities that go beyond gross assessment of anatomical abnormalities and allow visualization and quantification of biochemical processes in vivo. Magnetic resonance imaging (MRI) not only provides anatomical information, but also offers a wide range of functional sequences that may aid the evaluation of cancerous lesions. Furthermore, MRI provides the opportunity to guide and monitor anticancer therapies noninvasively. The aim of this review is to highlight some of the most promising developments of MRI in the functional assessment of cancer and the guidance and monitoring of (novel) anticancer therapies.