Pandemic potential of avian influenza A (H7N9) viruses

被引：99

作者：

Watanabe, Tokiko ^{[1
,2
,3
]}

Watanabe, Shinji ^{[2
,4
]}

Maher, Eileen A. ^{[1
]}

Neumann, Gabriele ^{[1
]}

Kawaoka, Yoshihiro ^{[1
,2
,3
,5
]}

机构：

[1] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53711 USA

[2] Japan Sci & Technol Agcy, ERATO Infect Induced Host Responses Project, Kawaguchi, Saitama 3320012, Japan

[3] Univ Tokyo, Inst Med Sci, Div Virol, Dept Microbiol & Immunol, Tokyo 1088639, Japan

[4] Miyazaki Univ, Lab Vet Microbiol, Dept Vet Sci, Miyazaki 8892192, Japan

[5] Univ Tokyo, Dept Special Pathogens, Int Res Ctr Infect Dis, Inst Med Sci, Tokyo 1088639, Japan

来源：

TRENDS IN MICROBIOLOGY | 2014年 / 22卷 / 11期

基金：

日本科学技术振兴机构;

关键词：

avian influenza H7N9 viruses; transmission; pandemic potential; AMINO-ACID SUBSTITUTIONS; HOST-RANGE DETERMINANTS; TO-PERSON TRANSMISSION; A(H7N9) VIRUS; HUMAN INFECTION; RECEPTOR-BINDING; CLINICAL FINDINGS; JIANGSU PROVINCE; MOLECULAR-BASIS; CHINA;

D O I：

10.1016/j.tim.2014.08.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Avian influenza viruses rarely infect humans, but the recently emerged avian H7N9 influenza viruses have caused sporadic infections in humans in China, resulting in 440 confirmed cases with 122 fatalities as of 16 May 2014. In addition, epidemiologic surveys suggest that there have been asymptomatic or mild human infections with H7N9 viruses. These viruses replicate efficiently in mammals, show limited transmissibility in ferrets and guinea pigs, and possess mammalian-adapting amino acid changes that likely contribute to their ability to infect mammals. In this review, we summarize the characteristic features of the novel H7N9 viruses and assess their pandemic potential.

引用

页码：623 / 631

页数：9

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