Solid-State Nuclear Magnetic Resonance in Pharmaceutical Compounds

被引:22
|
作者
Alberto Monti, Gustavo [1 ,2 ]
Karina Chattah, Ana [1 ,2 ]
Garro Linck, Yamila [2 ]
机构
[1] FaMAF Univ Nacl Cordoba, Cordoba, Argentina
[2] IFEG CONICET, Cordoba, Argentina
来源
ANNUAL REPORTS ON NMR SPECTROSCOPY, VOL 83 | 2014年 / 83卷
关键词
SSNMR; Pharmaceutical compounds; Characterization; NMR crystallography; Polymorphism; Complexes; C-13 CPMAS NMR; QUANTITATIVE CROSS-POLARIZATION; CRYSTAL-STRUCTURE; SUPRAMOLECULAR COMPLEXES; MAS NMR; STRUCTURAL-CHARACTERIZATION; DISSOLUTION PROPERTIES; FUROSEMIDE POLYMORPHS; ROTARY RESONANCE; CRYSTALLOGRAPHY;
D O I
10.1016/B978-0-12-800183-7.00004-6
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
The solid-state characterization of novel pharmaceutical compounds remains an important issue. Solid-state NMR is one of the techniques of choice to gain information when other techniques are not available. Knowledge of the molecular structure in the solid state can lead to better design and control the behaviour of the drug as it affects important properties such as solubility in aqueous medium. Many different NMR experiments can be performed to obtain either structural or dynamic information on very broad space and time ranges, respectively. Contrary to others techniques, not only crystalline material but also amorphous materials can be studied by SSNMR. These and other aspects make SSNMR a very powerful technique to obtain relevant information on solids pharmaceutical forms. We will discuss the SSNMR most common experiments used to investigate pharmaceutical compounds, including one-and two-dimensional experiments and relaxation time measurements. Additionally, we will mention some aspects of first principle calculation. Also we highlight the importance of NMR as a multinuclear technique. We will focus on SSNMR applied for characterization of new developed active pharmaceutical compounds and formulated drugs. We will pay attention to some particular topics as polymorphism, complexes with cyclodextrin and an emerging issue in pharmaceutical industry as it is the development of cocrystals. NMR crystallography is also discussed.
引用
收藏
页码:221 / 269
页数:49
相关论文
共 50 条
  • [41] Solid-state nuclear magnetic resonance and infrared spectroscopy of alkali feldspars
    周玲棣
    郭九皋
    杨年华
    李丽云
    Science in China(Series D:Earth Sciences), 1997, (02) : 159 - 165
  • [42] Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation
    van der Wel, Patrick C. A.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2024, 52 (02) : 719 - 731
  • [43] Solid-state nuclear magnetic resonance characterization of gramicidin channel structure
    Cross, TA
    SOLID-PHASE PEPTIDE SYNTHESIS, 1997, 289 : 672 - +
  • [44] On the Fer expansion: Applications in solid-state nuclear magnetic resonance and physics
    Mananga, Eugene Stephane
    PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 2016, 608 : 1 - 41
  • [45] Theory of Stochastic dipolar recoupling in solid-state nuclear magnetic resonance
    Tycko, Robert
    JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (19): : 6114 - 6121
  • [46] Solid-state nuclear magnetic resonance and infrared spectroscopy of alkali feldspars
    Zhou, LD
    Guo, JG
    Yang, NH
    Li, LY
    SCIENCE IN CHINA SERIES D-EARTH SCIENCES, 1997, 40 (02): : 159 - 165
  • [47] SOLID-STATE NUCLEAR MAGNETIC-RESONANCE STRUCTURAL STUDIES OF PROTEINS
    OPELLA, SJ
    STEWART, PL
    METHODS IN ENZYMOLOGY, 1989, 176 : 242 - 275
  • [48] Solid-state nuclear magnetic resonance as a tool for investigating the halogen bond
    Cerreia Vioglio, P.
    Chierotti, M. R.
    Gobetto, R.
    CRYSTENGCOMM, 2016, 18 (48): : 9173 - 9184
  • [49] Solid-State Nuclear Magnetic Resonance Techniques for Polymer Quantitative Investigation
    Shu, Jie
    Gu, Jiali
    Zhao, Huipeng
    PROGRESS IN CHEMISTRY, 2018, 30 (12) : 1844 - 1851
  • [50] Mesomorphism in columnar phases studied by solid-state nuclear magnetic resonance
    Dvinskikh, Sergey V.
    Thaning, Johan
    Stevensson, Baltzar
    Jansson, Kjell
    Kumar, Sandeep
    Zimmermann, Herbert
    Maliniak, Arnold
    PHYSICAL REVIEW E, 2006, 74 (02):