Results of the first-in-human study of ABBV-075 (mivebresib), a pan-inhibitor of bromodomain (BD) and extra terminal (BET) proteins, in patients (pts) with relapsed/refractory (R/R) solid tumors.

被引:4
|
作者
Piha-Paul, Sarina Anne
Sachdev, Jasgit C.
Barve, Minal A.
LoRusso, Patricia
Szmulewitz, Russell Zelig
Patel, Sapna Pradyuman
McKee, Mark D.
Wolff, Johannes E.
Hu, Beibei
Sood, Anjla
Chen, Xiaotian
Wilson, Sarah C.
O'Neil, Bert H.
机构
[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[2] HonorHealth Res Inst TGen, Scottsdale, AZ USA
[3] Mary Crowley Canc Res Ctr, Dallas, TX USA
[4] Yale Canc Ctr, New Haven, CT USA
[5] Univ Chicago, Chicago, IL 60637 USA
[6] AbbVie Inc, N Chicago, IL USA
[7] Indiana Univ Sch Med, Indianapolis, IN 46202 USA
关键词
D O I
10.1200/JCO.2018.36.15_suppl.2510
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2510
引用
收藏
页数:1
相关论文
共 50 条
  • [31] A Phase 1 First-in-Human Study of the Anti-CD38 Dimeric Fusion Protein TAK-169 for the Treatment of Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM) Who Are Proteasome Inhibitor (PI)- and Immunomodulatory Drug ( IMiD)-Refractory, Including Pts Relapsed/Refractory (R/R) or Naive to Daratumumab (dara)
    Kumar, Shaji K.
    Cornell, Robert F.
    Landgren, Ola
    Ailawadhi, Sikander
    Higgins, Jack P.
    Willert, Erin K.
    Waltzman, Roger
    Lin, Jianchang
    Zhang, Yuhong
    Lublinsky, Anya R.
    Dash, Ajeeta B.
    Hanley, Michael
    Manoharan, Divya
    Leichter, Morgan
    Ottinger, Sean
    Labotka, Richard J.
    Newcomb, John
    Vorog, Alexander
    BLOOD, 2019, 134
  • [32] CC-90011 in patients (Pts) with advanced solid tumors (STs) and relapsed/refractory non-Hodgkin lymphoma (R/R NHL): Updated results of a phase I study
    Hollebecque, A.
    de Bono, J. S.
    Salvagni, S.
    Plummer, R.
    Niccoli, P.
    Capdevila, J.
    Curigliano, G.
    Moreno, V.
    De Braud, F.
    Lopez-Brea, M.
    Martin-Romano, P.
    Baudin, E.
    Arias, M.
    De Alvaro, J.
    Parra-Palau, J.
    Sanchez-Perez, T.
    Aronchik, I.
    Filvaroff, E.
    Lamba, M.
    Nikolova, Z.
    ANNALS OF ONCOLOGY, 2020, 31 : S6 - S6
  • [33] First-in-human study of AZD5153, a small molecule inhibitor of bromodomain protein 4 (BRD4), in patients (pts) with relapsed/refractory (RR) malignant solid tumor and lymphoma: Preliminary data.
    Wang, Judy Sing-Zan
    De Vita, Serena
    Karlix, Janet L.
    Cook, Carl
    Littlewood, Gillian M.
    Hattersley, Maureen M.
    Moorthy, Ganesh
    Edlund, Helena
    Fabbri, Giulia
    Sachsenmeier, Kris F.
    Davison, Chris
    Clark, Edwin
    Moore, Kathleen N.
    Bauer, Todd Michael
    Ulahannan, Susanna Varkey
    Patel, Manish R.
    Hamilton, Erika Paige
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [34] Updated results of a phase I first-in-human study of the BCL-2 inhibitor ABT-199 (GDC-0199) in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)
    Seymour, John Francis
    Davids, Matthew Steven
    Pagel, John M.
    Kahl, Brad S.
    Wierda, William G.
    Miller, Thomas P.
    Gerecitano, John F.
    Kipps, Thomas J.
    Anderson, Mary Ann
    Huang, David C. S.
    Darden, David E.
    Gressick, Lori A.
    Nolan, Cathy E.
    Yang, Jianning
    Busman, Todd A.
    Graham, Alison M.
    Cerri, Elisa
    Enschede, Sari H.
    Humerickhouse, Rod A.
    Roberts, Andrew Warwick
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
  • [35] First Results from a Phase 1, First-in-Human Study of the Bruton's Tyrosine Kinase (BTK) Degrader Bgb-16673 in Patients (Pts) with Relapsed or Refractory (R/R) B-Cell Malignancies (BGB-16673-101)
    Seymour, John F.
    Cheah, Chan Yoon
    Parrondo, Ricardo
    Thompson, Meghan C.
    Stevens, Don A.
    Lasica, Masa
    Wang, Michael L.
    Kumar, Abhijeet
    Trotman, Judith
    Alwan, Maan
    Ding, Wei
    By, Kunthel
    Tariq, Bilal
    Chen, Xiangmei
    Fabre, Shannon
    Paik, Jason
    Agarwal, Amit
    Tam, Constantine S.
    BLOOD, 2023, 142
  • [36] First-in-human study of ABBV-706, a seizure-related homolog protein 6 (SEZ6)-targeting antibody-drug conjugate (ADC), in patients (pts) with advanced solid tumors.
    Chandana, Sreenivasa R.
    Choudhury, Noura J.
    Dowlati, Afshin
    Chiang, Anne C.
    Garmezy, Benjamin
    Kim, Joo-Hang
    Byers, Lauren Averett
    Ahn, Myung-Ju
    Kim, Tae Min
    Kim, Young-Chul
    Han, Ji-Youn
    Bar, Jair
    Zha, Jiuhong
    Henner, William
    Robinson, Randy
    Kohlhapp, Fred
    Hingorani, Pooja
    Papadopoulos, Kyriakos P.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [37] First-in-human phase 1 study of TAK-931, an oral cell division cycle 7 (CDC7) inhibitor, in patients (pts) with advanced solid tumors.
    Shimizu, Toshio
    Doi, Toshihiko
    Kondo, Shunsuke
    Takahashi, Hideaki
    Yamamoto, Noboru
    Sheldon-Waniga, Emily
    Zhou, Xiaofei
    Bahamon, Brittany
    Li, Hongmei
    Kuboki, Yasutoshi
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [38] First-in-human study of AMG 820, a monoclonal anti-CSF-1R (c-fms) antibody, in patients (pts) with advanced solid tumors
    Papadopoulos, Kyriakos
    Gluck, Larry
    Martin, Lainie P.
    Olszanski, Anthony J.
    Ngarmchamnanrith, Gateree
    Rasmussen, Erik
    Amore, Benny
    Nagorsen, Dirk
    Hill, John S.
    Stephenson, Joe
    CANCER RESEARCH, 2016, 76
  • [39] Results of a first-in-human, phase I/II trial of ASP2215, a selective, potent inhibitor of FLT3/Axl in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML)
    Levis, Mark J.
    Perl, Alexander E.
    Altman, Jessica K.
    Cortes, Jorge E.
    Ritchie, Ellen K.
    Larson, Richard A.
    Smith, Catherine Choy
    Wang, Eunice S.
    Strickland, Stephen Anthony
    Baer, Maria R.
    Litzow, Mark Robert
    Claxton, David
    Schiller, Gary J.
    Ustun, Celalettin
    Liu, Charles
    Gill, Stan
    Sargent, Briana
    Bahceci, Erkut
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [40] A first-in-human, open-label, phase I trial of daily oral PCLX-001, an NMT inhibitor, in patients with relapsed/refractory B-cell lymphomas and advanced solid tumors.
    Sangha, Randeep S.
    Jamal, Rahima
    Spratlin, Jennifer L.
    Kuruvilla, John
    Sehn, Laurie Helen
    Weickert, Michael
    Berthiaume, Luc G.
    Mackey, John Robert
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)