Enantioselective total synthesis of the highly oxygenated 1,10-seco-eudesmanolides eriolanin and eriolangin

被引：32
|
作者：
Merten, J
Fröhlich, R
Metz, P
机构：
[1] Tech Univ Dresden, Inst Organ Chem, D-01069 Dresden, Germany
[2] Univ Munster, Inst Organ Chem, D-4400 Munster, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 44期
关键词：
domino reactions; natural products; sulfur heterocycles; terpenoids; total synthesis;
D O I：
10.1002/anie.200460936
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sultones of swing: A sultone served as the key intermediate in the first enantioselective total syntheses of the bioactive title compounds (see scheme), the absolute configuration of which is now established. Starting from 2-bromo-1-(2-furyl)ethanone, 24 steps were required to generate the common basic structure, and in each case two additional steps yielded the natural products.
引用
收藏
页码：5991 / 5994
页数：4
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