YM-266183 and YM-266184, novel thiopeptide antibiotics produced by Bacillus cereus isolated from a marine sponge -: I.: Taxonomy, fermentation, isolation, physico-chemical properties and biological properties

被引：47
|
作者：
Nagai, K
Kamigiri, K
Arao, N
Suzumura, K
Kawano, Y
Yamaoka, M
Zhang, HP
Watanabe, M
Suzuki, K
机构：
[1] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Microbiol Labs, Itabashi Ku, Tokyo 1748511, Japan
[2] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Anal & Metab Labs, Tsukuba, Ibaraki 3058585, Japan
[3] Natl Inst Adv Ind Sci & Technol, Cent 6, Res Inst Biol Resources, Tsukuba, Ibaraki 3058566, Japan
[4] Fudan Univ, Sch Pharm, Shanghai 200032, Peoples R China
来源：
JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 02期
关键词：
D O I：
10.7164/antibiotics.56.123
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Novel antibiotics, YM-266183 (1) and YM-266184 (2), were found in the culture broth of Bacillus cereus QN03323 which was isolated from. the marine sponge Halichondria japonica. The structures of both antibiotics were determined by several spectroscopic experiments as new thiopeptide compounds. They exhibited potent antibacterial activities against staphylococci and enterococci including multiple drug resistant strains, whereas they were inactive against Gram-negative bacteria.
引用
收藏
页码：123 / 128
页数：6
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