Highly regio- and stereoselective copper(I) chloride-mediated carbometallation of 2,3-allenols with Grignard reagents

被引：18

作者：

Lu, Zhan

Ma, Shengming ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Lab Mol Recognit & Synth, Hangzhou 310027, Zhejiang, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 07期

关键词：

2,3-allenols; carbometallation; coupling; Grignard reagents; iodination;

D O I：

10.1002/adsc.200600532

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient highly regio- and stereoselective copper(I) chloride-mediated carbometallation of differently substituted 2,3-allenols with primary or secondary alkyl or aromatic Grignard reagents followed by iodination to synthesize fully-substituted allylic alcohols has been developed. This protocol introduces the R-4 group from the Grignard reagent to the terminal position of the 2,3-allenols.

引用

页码：1225 / 1230

页数：6

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