Highly regio- and stereoselective copper(I) chloride-mediated carbometallation of 2,3-allenols with Grignard reagents

被引：18
|
作者：
Lu, Zhan
Ma, Shengming [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Lab Mol Recognit & Synth, Hangzhou 310027, Zhejiang, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 07期
关键词：
2,3-allenols; carbometallation; coupling; Grignard reagents; iodination;
D O I：
10.1002/adsc.200600532
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An efficient highly regio- and stereoselective copper(I) chloride-mediated carbometallation of differently substituted 2,3-allenols with primary or secondary alkyl or aromatic Grignard reagents followed by iodination to synthesize fully-substituted allylic alcohols has been developed. This protocol introduces the R-4 group from the Grignard reagent to the terminal position of the 2,3-allenols.
引用
收藏
页码：1225 / 1230
页数：6
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