Bronchoalveolar lavage fluid IMMY Sona Aspergillus lateral-flow assay for the diagnosis of invasive pulmonary aspergillosis: a prospective, real life evaluation

被引：5
|
作者：
Arkell, P. [1 ,2 ,3 ]
Mahboobani, S. [4 ]
Wilson, R. [2 ,3 ,5 ,6 ]
Fatania, N. [7 ]
Coleman, M. [8 ]
Borman, A. M. [9 ,10 ]
Johnson, E. M. [9 ,10 ]
Armstrong-James, D. P. H. [1 ,2 ]
Abdolrasouli, A. [2 ]
机构：
[1] Imperial Coll Healthcare NHS Trust, Dept Infect Dis, London, England
[2] Imperial Coll London, Dept Infect Dis, London, England
[3] Imperial Coll London, Hammersmith Hosp, Ctr Antimicrobial Optimisat, Du Cane Rd, London W12 0NN, England
[4] Imperial Coll Healthcare NHS Trust, Dept Radiol, London, England
[5] Imperial Coll London, Natl Inst Hlth Res Hlth Protect Res Unit Healthca, Hammersmith Campus,Du Cane Rd, London W12 0NN, England
[6] Imperial Coll Healthcare NHS Trust, Pharm Dept, London, England
[7] Imperial Coll Healthcare NHS Trust, Dept Med Microbiol, North West London Pathol NWLP, London, England
[8] Imperial Coll Healthcare NHS Trust, Dept Resp Med, London, England
[9] Natl Infect Serv, Natl Mycol Reference Lab, Bristol BS10 5NB, Avon, England
[10] Univ Exeter, Ctr Med Mycol MRC CMM, MRC, Exeter EX4 4QD, Devon, England
来源：
MEDICAL MYCOLOGY | 2021年 / 59卷 / 04期
关键词：
invasive pulmonary aspergillosis; diagnosis; rapid diagnostic test; point-of-care; IMMY Sona; bronchoalveolar lavage fluid;
D O I：
10.1093/mmy/myaa113
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Prompt and reliable diagnosis of invasive pulmonary aspergillosis (IPA) is essential for early initiation of antifungal therapy. We evaluated bronchoalveolar lavage (BAL) fluid IMMY Sona Aspergillus lateral-flow assay (IMMY LFA) in 92 individuals with suspected pulmonary infection. Sensitivity and specificity (vs. host factor but no IPA) of BAL IMMY LFA for diagnosis of IPA in individuals with any European Organisation for Research and Treatment of Cancer-defied "host factor" were 67% and 85%, respectively. Performance appeared better in individuals with renal transplantation (100%, 100%), compared to those with hematological malignancy and/or allogenic stem cell transplantation (70%, 78%). We found BAL IMMY LFA to be a convenient and useful addition to our diagnostic armory for IPA. Lay abstract We evaluated a new test for diagnosing invasive pulmonary aspergillosis from bronchoscopy samples. We tested 92 people and found that it was 67% sensitive and 85% specific (compared to diagnosis according to a set of internationally recognised criteria). We found this test convenient and useful.
引用
收藏
页码：404 / 408
页数：5
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