Oncogenic mechanisms of the Helicobacter pylori CagA protein

被引：590
|
作者：
Hatakeyama, M [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Sci, Div Mol Oncol, Inst Med Genet, Sapporo, Hokkaido 0600815, Japan
[2] Hokkaido Univ, Grad Sch Sci, Div Chem, Sapporo, Hokkaido 0600815, Japan
来源：
NATURE REVIEWS CANCER | 2004年 / 4卷 / 09期
关键词：
D O I：
10.1038/nrc1433
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Infection with strains of Helicobacter pylori that carry the cytotoxin-associated antigen A (cagA) gene is associated with gastric carcinoma. Recent studies have shed light on the mechanism through which the cagA gene product, CagA, elicits pathophysiological actions. CagA is delivered into gastric epithelial cells by the bacterial type IV secretion system, where it deregulates the SHP2 oncoprotein. Intriguingly, CagA is noted for its variation, particularly at the SHP2-binding site, which could affect the potential of different strains of H. pylori to promote gastric carcinogenesis.
引用
收藏
页码：688 / 694
页数：7
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