Sodium-lithium countertransport: physiology and function

被引：37

作者：

West, IC ^{[1
]}

Rutherford, PA

Thomas, TH

机构：

[1] Univ Newcastle Upon Tyne, Sch Med, Dept Biochem & Genet, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Univ Wales Coll Med, Wrexham Maelor Hosp, Inst Nephrol, Wrexham, Clwyd, Wales

[3] Univ Newcastle Upon Tyne, Dept Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

JOURNAL OF HYPERTENSION | 1998年 / 16卷 / 01期

关键词：

sodium-lithium countertransport; adult polycystic kidney disease; diabetic nephropathy; diabetes; hyperlipidaemia; primary hypertension;

D O I：

10.1097/00004872-199816010-00002

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Current opinions on the relationships between erythrocyte sodium-lithium countertransport kinetics and primary hypertension, hyperlipidaemia and diabetic disease nephropathy are reviewed. Problems associated with the assay are analysed. Some possible mechanisms that could modify the kinetics of ion exchange are examined. The question of what catalyses sodium-lithium countertransport is discussed, but not answered. Some models are put forward showing how a study of sodium-lithium countertransport kinetics could further our understanding of important disease processes. (C) 1998 Rapid Science Ltd.

引用

页码：3 / 13

页数：11

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