Zirconocene-mediated synthesis of 3,4-disubstituted piperidines and reduced isoquinolines

被引：0
|
作者：
Kemp, MI
Whitby, RJ [1 ]
Coote, SJ
机构：
[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England
[2] Glaxo Wellcome Med Res Ctr, Stevenage SG1 2NY, Herts, England
来源：
SYNTHESIS-STUTTGART | 1998年
关键词：
zirconocene-mediated cyclisation; zirconabicycles; 3,4-disubstituted piperidines; isoquinolines;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Intramolecular cocyclisation of 4-azaocta-1,7-dienes, -1-en-7-ynes, -7-en-1-ynes and -1,7-diynes using 'zirconocene' equivalents affords 3-aza-8-zirconabicyclo[4.3.0]nonanes, -6-enes, -9-enes or -6,9-dienes. Protonolysis, iodinolysis, or carbonylation of these complexes affords 3,4-disubstituted piperidines. Exocyclic 1,3-dienes formed from the coupling/protonolysis of 4-azaocta-1,7-diynes react with activated dienophiles to yield reduced isoquinolines.
引用
收藏
页码：557 / 568
页数：12
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