Simultaneous determination of dopamine and ascorbic acid at a poly(toluidine blue) modified electrode

A novel polymer modified electrode is discussed in this paper. This resulting electrode can catalyze remarkably toward the electrochemical oxidations of dopamine (DA) and ascorbic acid (AA). Moreover, it can clearly discriminate the electrochemical oxidations of DA from that of AA based on their semi-derivative voltammograms. Hence, a simultaneous determination of DA and AA based on semi-derivative voltammetry at a poly(toluidine blue) modified electrode is suggested. The detection linear range for DA is 0.4 mumol L-1 - 1.5 mmol L-1, and AA 0.2 mumol L-1 - 2.4 mmol L-1, respectively. The resulting modified electrode was tentatively used to determine DA and AA in brain tissue.