A free boundary problem arising from DCIS mathematical model

被引:6
|
作者
Li, Heng [1 ]
Xu, Yongzhi [1 ]
Zhou, Jian-Rong [2 ]
机构
[1] Univ Louisville, Dept Math, Louisville, KY 40292 USA
[2] Foshan Univ, Dept Math, Foshan 528000, Guangdong, Peoples R China
关键词
nonlinear parabolic equation; free boundary problem; numerical solution; ductal carcinoma in situ (DCIS) model; CARCINOMA IN-SITU; GROWTH; TUMORS; INHIBITORS; ABSENCE;
D O I
10.1002/mma.4246
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
Ductal carcinoma in situ - a special cancer - is confined within the breast ductal only. We derive the mathematical ductal carcinoma in situ model in a form of a nonlinear parabolic equation with initial, boundary, and free boundary conditions. Existence, uniqueness, and stability of problem are proved. Algorithm and illustrative examples are included to demonstrate the validity and applicability of the technique in this paper. Copyright (c) 2016 John Wiley & Sons, Ltd.
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页码:3566 / 3579
页数:14
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