Applications of Mannich Reaction in Total Syntheses of Natural Products

被引：48
|
作者：
Heravi, Majid M. [1 ]
Zadsirjan, Vahideh [1 ]
Savadjani, Zahra Bozorgpour [1 ]
机构：
[1] Alzahra Univ, Sch Sci, Dept Chem, Tehran, Iran
来源：
CURRENT ORGANIC CHEMISTRY | 2014年 / 18卷 / 22期
关键词：
Alkaloid; Mannich reaction; natural product; total syntheses; ENANTIOSELECTIVE TOTAL-SYNTHESIS; ASYMMETRIC TOTAL-SYNTHESIS; PLANT ANTITUMOR AGENTS; ONE-STEP SYNTHESIS; FORMAL SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; MARINE SPONGE; PHYSICOCHEMICAL PROPERTIES; ABSOLUTE STEREOCHEMISTRY; CONFORMATIONAL-ANALYSIS;
D O I：
10.2174/1385272819666141014212254
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Mannich reaction has captured great attention and found usefulness as one of the most powerful synthetic methodologies for the carbon-carbon bond formation. Mannich reaction is also found to have a variety of applications in the total syntheses of natural and biologically active compounds in their crucial C-C bond forming steps. The present review is focused on the applications of Mannich reaction in total syntheses of natural products and some other complex targets.
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页码：2857 / 2891
页数：35
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