Chiral Primary-Secondary Diamines Catalyzed Michael-Aldol-Dehydration Reaction between Benzoylacetates and α,β-Unsaturated Ketones: Highly Enantioselective Synthesis of Functionalized Chiral Cyclohexenones

被引：44
|
作者：
Yang, Ying-Quan [1 ]
Chai, Zhuo [2 ]
Wang, Hai-Feng [2 ]
Chen, Xing-Kuan [2 ]
Cui, Hai-Feng [2 ]
Zheng, Chang-Wu [2 ]
Xiao, Hua [1 ]
Li, Peng [2 ]
Zhao, Gang [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2009年 / 15卷 / 48期
基金：
中国国家自然科学基金;
关键词：
aldol reaction; asymmetric catalysis; enones; Michael reaction; organocatalysis; OPTICALLY-ACTIVE 5-(TERT-BUTYLDIMETHYLSILOXY)-2-CYCLOHEXENONE; CYCLOHEXANE RINGS; BUILDING-BLOCKS; ORGANOCATALYSIS; CONDENSATION; ALDEHYDES; ENONES;
D O I：
10.1002/chem.200901541
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
"Chemical Equation Presented" A highly enantioselective organocatalytic tandem Michael-aldol-dehydration reaction that provides an expedited access to highly functionalized chiral cyclohexenone derivatives (such as that depicted) by using a simple diamine catalyst is described. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：13295 / 13298
页数：4
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