Study of β-blockers/β-cyclodextrins inclusion complex by NMR, DSC, X-ray and SEM investigation

被引：51
|
作者：
Ficarra, R
Ficarra, P [1 ]
Di Bella, MR
Raneri, D
Tommasini, S
Calabrò, ML
Gamberini, MC
Rustichelli, C
机构：
[1] Univ Messina, Fac Farm, Dipartimento Farmacochim, I-98168 Messina, Italy
[2] Univ Catanzaro, Fac Farm, I-88021 Roccelletta Di Borgia, CZ, Italy
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2000年 / 23卷 / 01期
关键词：
atenolol; celiprolol; beta-cyclodextrin; nuclear magnetic resonance (NMR); differential scanning calorimetry (DSC); X-ray powder diffractometry (XRD); scanning electron microscopy (SEM);
D O I：
10.1016/S0731-7085(00)00261-2
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The formation of inclusion complexes between beta-cyclodextrin with the two beta-blockers, atenolol and celiprolol, have been studied in the aqueous environment and in the solid state by nuclear magnetic resonance (NMR) spectroscopy, X-ray, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) techniques. The magnitude of the chemical shirts of the interior and exterior beta-cyclodextrin protons in the presence of each beta-blocker indicated that these are included within the beta-cyclodextrin cavity. In aqueous solution they form 1:1 complexes. In the solid state the formation of the beta-cyclodextrin/atenolol (celiprolol) complexes is confirmed by X-ray, DSC and SEM, also employed to characterize pure substances and their physical mixtures. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：33 / 40
页数：8
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