A simple aptamer-functionalized gold nanorods based biosensor for the sensitive detection of MCF-7 breast cancer cells

被引：75
|
作者：
Li, Yuan [1 ,2 ]
Zhang, Yulong [1 ]
Zhao, Man [1 ]
Zhou, Qianqian [1 ]
Wang, Lili [2 ]
Wang, Huizhong [3 ]
Wang, Xiaohui [1 ,4 ]
Zhan, Linsheng [1 ]
机构：
[1] Beijing Inst Transfus Med, Beijing Key Lab Blood Safety & Supply Technol, Beijing 100850, Peoples R China
[2] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemobiosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
[3] 305th Hosp Chinese PLA, Beijing 100017, Peoples R China
[4] Nankai Univ, Minist Educ, Key Lab Adv Energy Mat Chem, Tianjin 300071, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 20期
关键词：
TUMOR-MARKER; DNA; DIAGNOSIS; BIOPSY;
D O I：
10.1039/c6cc01014h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we describe a novel approach for the rapid diagnosis of human breast carcinoma MCF-7 cells with a detection limit of 100 cells mL(-1). In our strategy, the MCF-7 cells are specially recognized by mucin 1 protein (MUC-1) aptamer-functionalized gold nanorods (GNRs) through specific interactions, whose signals are simply read out by its unique localized surface plasmon resonance (LSPR) spectra.
引用
收藏
页码：3959 / 3961
页数：3
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