Process development and pilot-scale synthesis of cefotetan

被引：7

作者：

Fujimoto, M ^{[1
]}

Maeda, T ^{[1
]}

Okumura, K ^{[1
]}

Uda, M ^{[1
]}

Nakamura, M ^{[1
]}

Kashiwagi, T ^{[1
]}

Tsunoda, T ^{[1
]}

机构：

[1] Yamanouchi Pharmaceut Co Ltd, Chem Technol Labs, Ibaraki 3180001, Japan

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 06期

关键词：

D O I：

10.1021/op049914m

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Strategies that were adopted during the process development of Cefotetan in order to achieve a cost-effective commercial-scale synthesis are described herein. These included replacement of the trifluoroacetic acid used for cleavage of the benzhydryl ester and the development of an alternative synthetic route. This work led to improvement of both the impurity profile and the yield of the process. The pilot-scale synthesis of Cefotetan is described in detail in the Experimental Section. The scaled-up process has been successfully used for the commercial manufacture of Cefotetan since 1983.

引用

页码：915 / 919

页数：5

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