Targeting mediator subunits CDK8/CDK19 for treatment of advanced prostate cancer.

被引:0
|
作者
Hupe, Marie C.
Offermann, Anne
Becker, Finn
Joerg, Vincent
Vogel, Wenzel
Braegelmann, Johannes
Perner, Sven
Merseburger, Axel Stuart
机构
[1] Univ Hosp Schleswig Holstein, Dept Urol, Campus Luebeck, Lubeck, Germany
[2] Univ Hosp Schleswig Holstein, Pathol, Campus Luebeck, Lubeck, Germany
[3] Leibniz Ctr Med & Biosci, Res Ctr Borstel, Lubeck, Germany
[4] Univ Cologne, Dept Translat Genom, Cologne, Germany
关键词
D O I
10.1200/JCO.2019.37.7_suppl.152
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
152
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potential
    Clarke, Paul
    Esdar, Christina
    Mallinger, Aurelie
    Schiemann, Kai
    Waalboer, Dennis
    Crumpler, Simon
    Rink, Christian
    Stieber, Frank
    Calderini, Michel
    Adeniji-Popoola, Olajumoke
    Ortiz-Ruiz, Maria-Jesus
    Samant, Rahul S.
    Czodrowski, Paul
    Musil, Djordje
    Schwarz, Daniel
    Schneider, Klaus
    Busch, Michael
    Stubbs, Mark
    Burke, Rosemary
    TePoele, Robert
    Gowan, Sharon
    Rohdich, Felix
    Raynaud, Florence
    Schneider, Richard
    Poeschke, Oliver
    Blaukat, Andree
    Urbahns, Klaus
    Workman, Paul
    Kaufmann, Wolfgang
    Simon, Stephanie
    Eccles, Suzanne A.
    Dale, Trevor
    Wienke, Dirk
    Blagg, Julian
    CANCER RESEARCH, 2016, 76
  • [22] Elucidation of the different roles of CDK8 and CDK19 in colorectal cancer (CRC) using CRISPR gene editing technology
    Ruiz, Maria J. Ortiz
    Popoola, Olajumoke
    Mallinger, Aurelie
    Gowan, Sharon
    Court, Will
    Box, Gary
    Valenti, Melanie
    Brandon, Alexis De Haven
    Te-Poele, Robert
    Workman, Paul
    Schiemann, Kai
    Esdar, Cristina
    Wienke, Dirk
    Blagg, Julian
    Clarke, Paul
    Eccles, Suzanne A.
    CANCER RESEARCH, 2016, 76
  • [23] Distinct roles for Mediator Cdk8 module subunits in Drosophila development
    Loncle, Nicolas
    Boube, Muriel
    Joulia, Laurent
    Boschiero, Claire
    Werner, Michel
    Cribbs, David L.
    Bourbon, Henri-Marc
    EMBO JOURNAL, 2007, 26 (04): : 1045 - 1054
  • [24] Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19
    Mallinger, Aurelie
    Schiemann, Kai
    Rink, Christian
    Stieber, Frank
    Calderini, Michel
    Crumpler, Simon
    Stubbs, Mark
    Adeniji-Popoola, Olajumoke
    Poeschke, Oliver
    Busch, Michael
    Czodrowski, Paul
    Musil, Djordje
    Schwarz, Daniel
    Ortiz-Ruiz, Maria-Jesus
    Schneider, Richard
    Thai, Ching
    Valenti, Melanie
    Brandon, Alexis de Haven
    Burke, Rosemary
    Workman, Paul
    Dale, Trevor
    Wienke, Dirk
    Clarke, Paul A.
    Esdar, Christina
    Raynaud, Florence I.
    Eccles, Suzanne A.
    Rohdich, Felix
    Blagg, Julian
    JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (03) : 1078 - 1101
  • [25] Inhibition of Cdk8/Cdk19 Activity Promotes Treg Cell Differentiation and Suppresses Autoimmune Diseases
    Guo, Zengli
    Wang, Gang
    Lv, Yanfang
    Wan, Yisong Y.
    Zheng, Junnian
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [26] Inhibition of CDK8/19 mediator kinase suppresses primary and metastatic growth of castrationresistant prostate cancer
    Li, Jing
    Hilimire, Thomas
    Cheng, Chen
    Broude, Eugenia V.
    Liu, Yueying
    Lilly, Michael B.
    Shiozawa, Yusuke
    Wilding, George
    Roninson, Igor B.
    Chen, Mengqian
    CANCER RESEARCH, 2022, 82 (12)
  • [27] Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions
    Steinparzer, Iris
    Sedlyarov, Vitaly
    Rubin, Jonathan D.
    Eislmayr, Kevin
    Galbraith, Matthew D.
    Levandowski, Cecilia B.
    Vcelkova, Terezia
    Sneezum, Lucy
    Wascher, Florian
    Amman, Fabian
    Kleinova, Renata
    Bender, Heather
    Andrysik, Zdenek
    Espinosa, Joaquin M.
    Superti-Furga, Giulio
    Dowell, Robin D.
    Taatjes, Dylan J.
    Kovarik, Pavel
    MOLECULAR CELL, 2019, 76 (03) : 485 - +
  • [28] Increased mediator complex subunit CDK19 expression associates with aggressive prostate cancer
    Becker, Finn
    Joerg, Vincent
    Hupe, Marie C.
    Roth, Doris
    Krupar, Rosemarie
    Lubczyk, Verena
    Kuefer, Rainer
    Sailer, Verena
    Duensing, Stefan
    Kirfel, Jutta
    Merseburger, Axel S.
    Braegelmann, Johannes
    Perner, Sven
    Offermann, Anne
    INTERNATIONAL JOURNAL OF CANCER, 2020, 146 (02) : 577 - 588
  • [29] CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF
    Dannappel, Marius, V
    Zhu, Danxi
    Sun, Xin
    Chua, Hui Kheng
    Poppelaars, Marle
    Suehiro, Monica
    Khadka, Subash
    Sian, Terry C. C. Lim Kam
    Sooraj, Dhanya
    Loi, Melissa
    Gao, Hugh
    Croagh, Daniel
    Daly, Roger J.
    Faridi, Pouya
    Boyer, Thomas G.
    Firestein, Ron
    JOURNAL OF CLINICAL INVESTIGATION, 2022, 132 (20):
  • [30] Functional characterization of novel transcription-regulating cancer drug targets, CDK8 and CDK19, using CRISPR/Cas9 knockout and a highly selective CDK8/19 kinase inhibitor
    Chen, Mengqian
    Hu, Bing
    Ji, Hao
    Altilia, Serena
    Liang, Jiaxin
    McDermott, Martina
    Lim, Chang-uk
    Porter, Donald C.
    Broude, Eugenia
    Roninson, Igor
    CANCER RESEARCH, 2017, 77