Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer Activity In Vitro

被引：12
|
作者：
Abu-Safieh, Kayed A. [1 ]
Abu-Surrah, Adnan S. [2 ]
Tabba, Hani D. [2 ]
AlMasri, Huda A. [1 ]
Bawadi, Randa M. [3 ]
Boudjelal, Fadila M. [3 ]
Tahtamouni, Lubna H. [4 ]
机构：
[1] Hashemite Univ, Dept Chem, POB 150459, Zarqa 13115, Jordan
[2] Qatar Univ, Coll Arts & Sci, Dept Chem & Earth Sci, POB 2713, Doha, Qatar
[3] Univ Jordan, Dept Physiol & Biochem, Amman 11942, Jordan
[4] Hashemite Univ, Dept Biol & Biotechnol, Zarqa 13115, Jordan
来源：
JOURNAL OF CHEMISTRY | 2016年 / 2016卷
关键词：
CHIRAL PALLADIUM(II); ANTITUMOR; DESIGN; AGENTS; ASSAYS;
D O I：
10.1155/2016/7508724
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
cis-Dichloro-palladium(II) and cis-dichloro-platinum(II) complexes (2, 4) of the general formula [M(N-N)Cl-2] (M=Pd(II) and Pt(II), N-N= 1,2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl) benzene, (DFMPB)) and the dicationic palladium(II) complex [Pd(N-N)(CH3CN)(2)](BF4)(2) (3) have been prepared and characterized by elemental analysis, H-1-NMR-, mass spectroscopy, and IR spectroscopy. The cytotoxic effect of these complexes against MDA-231 and MCF-7 human breast cancer cell lines and K562 human leukemia cell line has been studied. The influence was dose dependent and varies with cell type. The palladium(II) complex (2) showed superior cytotoxic effect compared with the corresponding platinum(II) complex and the standard, cisplatin, when tested against all the above cell lines.
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页数：7
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