PI3K Inhibitor Increased Radiosensitizing Effect of PARP Inhibitor in BRCA-Proficient Triple Negative Breast Cancer Cells

被引:0
|
作者
Kim, I. A. [1 ,2 ]
Jang, N. Y. [3 ]
Kim, D. H. [2 ]
Cho, B. J. [4 ]
Choi, E. J. [2 ]
机构
[1] Seoul Natl Univ, Seoul, South Korea
[2] Seoul Natl Univ, Bundang Hosp, Med Sci Res Inst, Songnam, South Korea
[3] Seoul Natl Univ, Grad Sch Med, Seoul, South Korea
[4] Seoul Natl Univ, Bundang Hosp, Med Sci Res Inst, Songnam, South Korea
关键词
D O I
10.1016/j.ijrobp.2015.07.1912
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3337
引用
收藏
页码:E533 / E534
页数:2
相关论文
共 50 条
  • [1] Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer
    Wang, Junwei
    He, Guangchao
    Li, Hui
    Ge, Yiran
    Wang, Shuping
    Xu, Yungen
    Zhu, Qihua
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 213
  • [2] PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition
    Ibrahim, Yasir H.
    Garcia-Garcia, Celina
    Serra, Violeta
    He, Lei
    Torres-Lockhart, Kristine
    Prat, Aleix
    Anton, Pilar
    Cozar, Patricia
    Guzman, Marta
    Grueso, Judit
    Rodriguez, Olga
    Teresa Calvo, Maria
    Aura, Claudia
    Diez, Orland
    Rubio, Isabel T.
    Perez, Jose
    Rodon, Jordi
    Cortes, Javier
    Ellisen, Leif W.
    Scaltriti, Maurizio
    Baselga, Jose
    CANCER DISCOVERY, 2012, 2 (11) : 1036 - 1047
  • [3] Therapeutic potential of the PI3K inhibitor LY294002 and PARP inhibitor Talazoparib combination in BRCA-deficient triple negative breast cancer cells
    Eskiler, Gamze Guney
    Ozturk, Melek
    CELLULAR SIGNALLING, 2022, 91
  • [4] Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
    Juvekar, Ashish
    Burga, Laura N.
    Hu, Hai
    Lunsford, Elaine P.
    Ibrahim, Yasir H.
    Balmana, Judith
    Rajendran, Anbazhagan
    Papa, Antonella
    Spencer, Katherine
    Lyssiotis, Costas A.
    Nardella, Caterina
    Pandolfi, Pier Paolo
    Baselga, Jose
    Scully, Ralph
    Asara, John M.
    Cantley, Lewis C.
    Wulf, Gerburg M.
    CANCER DISCOVERY, 2012, 2 (11) : 1048 - 1063
  • [5] The CDK1 inhibitor RO3306 improves the response of BRCA-proficient breast cancer cells to PARP inhibition
    Xia, Qing
    Cai, Yuchen
    Peng, Roujun
    Wu, Guosheng
    Shi, Yanxia
    Jiang, Wenqi
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 44 (03) : 735 - 744
  • [6] Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia
    Oei, Arlene L.
    van Leeuwen, Caspar M.
    Ahire, Vidhula R.
    Rodermond, Hans M.
    ten Cate, Rosemarie
    Westermann, Anneke M.
    Stalpers, Lukas J. A.
    Crezee, Johannes
    Kok, H. Petra
    Krawczyk, Przemek M.
    Kanaar, Roland
    Franken, Nicolaas A. P.
    ONCOTARGET, 2017, 8 (17) : 28116 - 28124
  • [7] Radiolytic Nanoparticle Delivery of Radiation Sensitizers for BRCA-Proficient Triple Negative Breast Cancer
    DuRoss, A. N.
    Rosch, J.
    Brown, A.
    Sahay, G.
    Jaboin, J. J.
    Thomas, C. R., Jr.
    Sun, C.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2017, 99 (02): : E586 - E587
  • [8] First PI3K Inhibitor for Breast Cancer
    Voelker, Rebecca
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 322 (01): : 19 - 19
  • [9] Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cells
    Choi, Eun
    Jeon, Kyung-Hwa
    Lee, Hanhee
    Mun, Gil-Im
    Kim, Jeong-Ahn
    Shin, Jae-Ho
    Kwon, Youngjoo
    Na, Younghwa
    Lee, Yun-Sil
    CANCER SCIENCE, 2024, 115 (06) : 2036 - 2048
  • [10] Novel combination therapy of DNMT inhibitor SGI-110 and PARP inhibitor BMN-673 (talazoparib) for BRCA-proficient ovarian cancer
    Pulliam, Nicholas
    Taverna, Pietro
    Lyons, John
    Nephew, Kenneth P.
    CANCER RESEARCH, 2015, 75