A convenient [hydroxy(tosyloxy)iodo]benzene-mediated one-pot synthesis of 2-arylimidazo[2,1-b]benzothiazoles

被引：12

作者：

Sumran, Garima ^{[1
]}

Aggarwal, Ranjana ^{[2
]}

机构：

[1] DAV Coll Lahore, Dept Chem, Ambala City 134002, Haryana, India

[2] Kurukshetra Univ, Dept Chem, Kurukshetra 136119, Haryana, India

来源：

JOURNAL OF SULFUR CHEMISTRY | 2015年 / 36卷 / 02期

关键词：

imidazo[2,1-b]benzothiazoles; hydroxy(tosyloxy)iodo]benzene; hypervalent iodine; 2-amino-6-(substituted)benzothiazoles; alpha-tosyloxyketones; REGIOSELECTIVE SYNTHESIS; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; SOLVENT-FREE; AGENTS; DERIVATIVES; INHIBITORS; MOIETY; WATER;

D O I：

10.1080/17415993.2014.996221

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several 2-arylimidazo[2,1-b]benzothiazoles (4) have been conveniently synthesized in one-pot reactions via alpha-tosyloxylation of enolizable ketones (1) using [hydroxy(tosyloxy)iodo]benzene 2 in acetonitrile, followed by treatment with 2-amino-6-(substituted)benzothiazoles (3). The present protocol offers several advantages towards general access of 2-arylimidazo[2,1-b]benzothiazoles, including an intriguing alternative to the literature protocols, a readily available nontoxic reagent, operational simplicity and an environmentally benign procedure.

引用

页码：170 / 177

页数：8

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