PINK1, a gene product of PARK6, accumulates in α-synucleinopathy brains

被引：24
|
作者：
Murakami, Tetsuro
Moriwaki, Yasuhiro
Kawarabayashi, Takeshi
Nagai, Makiko
Ohta, Yasuyuki
Deguchi, Kentaro
Kurata, Tomoko
Morimoto, Nobutoshi
Takehisa, Yasushi
Matsubara, Etsuro
Ikeda, Masaki
Harigaya, Yasuo
Shoji, Mikio
Takahashi, Ryosuke
Abe, Koji
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Okayama 7008558, Japan
[2] Kyoritsu Univ Pharm, Dept Clin Pharm, Div Pharmacol, Tokyo, Japan
[3] Natl Ctr Geriatr & Gerontol, Dept Alzheimers Dis Res, Natl Inst Longev Sci, Aichi, Japan
[4] Gunma Univ, Dept Neurol, Grad Sch Med, Gunma, Japan
[5] Maebashi Red Cross Hosp, Dept Neurol, Gunma, Japan
[6] Hirosaki Univ, Sch Med, Dept Neurol Sci, Inst Brain Sci, Hirosaki, Aomori 036, Japan
[7] Kyoto Univ, Dept Neurol, Grad Sch Med, Kyoto, Japan
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2007年 / 78卷 / 06期
关键词：
D O I：
10.1136/jnnp.2006.100123
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
引用
收藏
页码：653 / 655
页数：4
相关论文
共 50 条
  • [41] Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells
    Zeng-li Zhang
    Na-na Wang
    Qi-lian Ma
    Yang Chen
    Li Yao
    Li Zhang
    Qiu-shi Li
    Min-hua Shi
    Hong-feng Wang
    Zheng Ying
    Acta Pharmacologica Sinica, 2020, 41 : 93 - 100
  • [42] The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury
    Wang, Ying
    Zhu, Jiefu
    Liu, Zhiwen
    Shu, Shaoqun
    Fu, Ying
    Liu, Yuxue
    Cai, Juan
    Tang, Chengyuan
    Liu, Yu
    Yin, Xiaoming
    Dong, Zheng
    REDOX BIOLOGY, 2021, 38
  • [43] Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells
    Zhang, Zeng-li
    Wang, Na-na
    Ma, Qi-lian
    Chen, Yang
    Yao, Li
    Zhang, Li
    Li, Qiu-shi
    Shi, Min-hua
    Wang, Hong-feng
    Ying, Zheng
    ACTA PHARMACOLOGICA SINICA, 2020, 41 (01) : 93 - 100
  • [44] Incidence of mutations in the PARK2, PINK1, PARK7 genes in Polish early-onset Parkinson disease patients
    Koziorowski, Dariusz
    Hoffman-Zacharska, Dorota
    Slawek, Jaroslaw
    Jamrozik, Zygmunt
    Janik, Piotr
    Potulska-Chromik, Anna
    Roszmann, Anna
    Tataj, Renato
    Bal, Jerzy
    Friedman, Andrzej
    NEUROLOGIA I NEUROCHIRURGIA POLSKA, 2013, 47 (04) : 319 - 324
  • [45] The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway
    Gao, Feng
    Chen, Dong
    Si, Jianmin
    Hu, Qingsong
    Qin, Zhenghong
    Fang, Ming
    Wang, Guanghui
    HUMAN MOLECULAR GENETICS, 2015, 24 (09) : 2528 - 2538
  • [46] Novel features in a patient homozygous for the L347P mutation in the PINK1 gene
    Doostzadeh, J.
    Tetrud, J. W.
    Allen-Auerbach, M.
    Langston, J. W.
    Schuele, B.
    PARKINSONISM & RELATED DISORDERS, 2007, 13 (06) : 359 - 361
  • [47] The Parkinson's disease gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
    Furlong, Rachel M.
    Lindsay, Andrew
    Anderson, Karen E.
    Hawkins, Phillip T.
    Sullivan, Aideen M.
    O'Neill, Cora
    JOURNAL OF CELL SCIENCE, 2019, 132 (20)
  • [48] Novel mutation in PINK1 gene causing autosomal recessive Parkinsonism in a large Tunisian family
    Amouri, Rim
    Ben Yahmed, Samia
    Kefi, Mounir
    Zouari, Mourad
    Hentati, Faycal
    NEUROLOGY, 2007, 68 (12) : A323 - A323
  • [49] Clinically Reported Heterozygous Mutations in the PINK1 Kinase Domain Exert a Gene Dosage Effect
    Tan, Eng-King
    Refai, F. Shaffra
    Siddique, Mobin
    Yap, Karen
    Ho, Patrick
    Fook-Chong, Stephanie
    Zhao, Yi
    HUMAN MUTATION, 2009, 30 (11) : 1551 - 1557
  • [50] Loss of PINK1 inhibits apoptosis by upregulating a-synuclein in inflammation -sensitized hypoxic-ischemic injury in the immature brains
    Zhu, Jianghu
    Qu, Yi
    Lin, Zhenlang
    Zhao, Fengyan
    Zhang, Li
    Huang, Yang
    Jiang, Changan
    Mu, Dezhi
    BRAIN RESEARCH, 2016, 1653 : 14 - 22
12345