Clinical significance of heat shock protein-70 expression in bladder cancer

被引：62
|
作者：
Syrigos, KN
Harrington, KJ
Karayiannakis, AJ
Sekara, E
Chatziyianni, E
Syrigou, EI
Waxman, J
机构：
[1] Univ Athens, Sch Med, Sotiria Gen Hosp, Dept Internal Med 3,Lab Mol Oncol, GR-11527 Athens, Greece
[2] Univ London Imperial Coll Sci Technol & Med, Dept Clin Oncol, London, England
来源：
UROLOGY | 2003年 / 61卷 / 03期
关键词：
D O I：
10.1016/S0090-4295(02)02289-6
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives. To investigate the expression of heat shock protein-70 (HSP-70) in transitional cell bladder cancer and correlate it with normal and inflammatory bladder tissue samples. Methods. We used a three-step avidin-biotin method to examine the localization of a rabbit anti-HSP-70 polyclonal antibody in normal (n = 10), inflammatory (n = 10), and malignant (n = 67) bladder tissue samples. Results. Fifty-eight percent of the bladder cancer samples and only 10% and 20% of the normal and inflammatory bladder tissue samples, respectively, expressed HSP-70. Localization of the antibody correlated with the grade (P <0.001), stage (P <0.001), and survival (P <0.05) of the patients with malignancy. Conclusions. HSP-70 is frequently overexpressed by bladder cancer cells and could be used as biochemical marker in patients with bladder cancer. (C) 2003, Elsevier Science Inc.
引用
收藏
页码：677 / 680
页数：4
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