Chemoenzymatic synthesis of building blocks for statin side chains

被引：141
|
作者：
Müller, M [1 ]
机构：
[1] Forschungszentrum Julich, Inst Biotechnol 2, D-52425 Julich, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 03期
关键词：
enzyme catalysis; inhibitors; natural products; statins; steroids;
D O I：
10.1002/anie.200460852
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Biocatalysis: Enzymatic transformations have become competitive methods for the synthesis of complex organic compounds. The wide range of possibilities offered by biocatalysis for the synthesis of target molecules are highlighted based on the example of the statins. This class of compounds, which includes rosuvastatin (see picture), are good inhibitors of cholesterol synthesis and dominate the market for cholesterol-lowering drugs.
引用
收藏
页码：362 / 365
页数：4
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