Synthesis, Computational Insights, and Anticancer Activity of Novel Indole-Schiff Base Derivatives

被引：7
|
作者：
Trivedi, Kunj M. [1 ]
Patel, Unnati P. [1 ]
Dabhi, Ranjit C. [1 ]
Maru, Jayesh J. [1 ]
机构：
[1] Gujarat Univ, Sch Sci, Dept Chem, Ahmadabad 380009, Gujarat, India
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2022年 / 48卷 / 03期
关键词：
indole; nucleophilic substitution reaction; imine formation; anti-lung cancer activity; docking; LUNG-CANCER; CHEMISTRY; SCAFFOLD; DESIGN;
D O I：
10.1134/S1068162022030116
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Synthetic and naturally available compounds with indole moiety are known to show significant biological activity. This paper describes computational insights and synthesis of novel indole clubbed Schiff base derivatives (IVa-j) with improved biological profile. Synthesized molecules were characterized by H-1 NMR and C-13 NMR spectroscopy. The prepared derivatives were evaluated for their in vitro anticancer activity against A549 cell line using MTT assay. Results revealed significant potential of the synthesized compounds, especially (IVb), which exhibited high anticancer activity.
引用
收藏
页码：601 / 608
页数：8
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