Feeding enriched omega-3 fatty acid beef to rats increases omega-3 fatty acid content of heart and liver membranes and decreases serum vascular cell adhesion molecule-1 and cholesterol levels

Dietary intake of the long-chain omega-3 fatty acids prevents the development of heart disease. In this study, we evaluated whether feeding beef from cattle fed an omega-3 fatty acid-enriched diet to rats had health benefits. Cattle raised on a 10% flaxseed diet have high amounts of alpha-linolenic acid in their muscle tissue when compared to cattle fed a control diet of corn. Twenty, weanling, Sprague-Dawley rats were fed one of two diets (n = 10 in each group), one diet containing fat from beef of cattle fed 10% flaxseed and the other beef from cattle fed a conventional com ration. The diets contained 10% fat from the cooked beef using a modification of the American Institute of Nutrition diet formulated in 1976 diet for a 5-week period. There was a statistically significant increase in the amount of membrane docosahexaenoic acid in the livers of the rats on the diet of beef from cattle fed flaxseed and a statistically significant increase in the amount of membrane arachidonic acid in the hearts of the controls. There were also strong, positive trends for the increases in the amounts of membrane docosahexaenoic acid in the hearts and membrane linoleic acid in the livers of the rats on the diet of beef from cattle fed flaxseed when compared with controls. Serum cholesterol and vascular cell adhesion molecule-1 levels were decreased in rats fed the beef from cattle fed flaxseed. These findings suggest that agriculture practice of feeding a high omega-3 fatty acid diet to cattle can produce positive health benefits to the consumer. (C) 2007 Elsevier Inc. All rights reserved.