Reverting to old theories of ageing with new evidence for the role of somatic mutations

被引：1
|
作者：
Franco, Irene [1 ]
Eriksson, Maria [2 ]
机构：
[1] IRCCS Osped San Raffaele, Cyst Kidney Disorders Unit, Div Genet & Cell Biol, Milan, Italy
[2] Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, Huddinge, Sweden
来源：
NATURE REVIEWS GENETICS | 2022年 / 23卷 / 11期
关键词：
D O I：
10.1038/s41576-022-00513-5
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
With age, somatic mutations accumulate in the genome of healthy individuals, but the functional outcome of this increased mutational load has been unclear. Recent sequencing data support a functional role for somatic mutations in ageing and age-associated diseases. Somatic mutations accumulate with age in the genome of healthy individuals. Franco and Eriksson posit that recent sequencing data indicate a functional role for this increased mutational load in ageing and age-associated diseases.
引用
收藏
页码：645 / 646
页数：2
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