Reverting to old theories of ageing with new evidence for the role of somatic mutations

被引：1

作者：

Franco, Irene ^{[1
]}

Eriksson, Maria ^{[2
]}

机构：

[1] IRCCS Osped San Raffaele, Cyst Kidney Disorders Unit, Div Genet & Cell Biol, Milan, Italy

[2] Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, Huddinge, Sweden

来源：

NATURE REVIEWS GENETICS | 2022年 / 23卷 / 11期

关键词：

D O I：

10.1038/s41576-022-00513-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

With age, somatic mutations accumulate in the genome of healthy individuals, but the functional outcome of this increased mutational load has been unclear. Recent sequencing data support a functional role for somatic mutations in ageing and age-associated diseases. Somatic mutations accumulate with age in the genome of healthy individuals. Franco and Eriksson posit that recent sequencing data indicate a functional role for this increased mutational load in ageing and age-associated diseases.

引用

页码：645 / 646

页数：2

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