Integration of signals to the Arp2/3 complex

被引：154
|
作者：
Weaver, AM [1 ]
Young, ME [1 ]
Lee, WL [1 ]
Cooper, JA [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Cell Biol, St Louis, MO 63130 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 01期
关键词：
D O I：
10.1016/S0955-0674(02)00015-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Arp2/3 complex is necessary for nucleating the formation of branched networks of actin filaments at the cell cortex, and an increasing number of proteins able to activate the Arp2/3 complex have been described. The Wiskott-Aldrich syndrome protein (WASP) family and cortactin comprise the large majority of the known activators. WASPs bind to Arp2/3 via an acidic (A) domain, and a WH2 domain appears to bring an actin monomer to Arp2/3, promoting the nucleation of the new filament. Cortactin also binds the Arp2/3 complex via an A domain; however, it also binds to actin filaments, which helps activate the Arp2/3 complex and stabilise the newly created branches between the filaments.
引用
收藏
页码：23 / 30
页数：8
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