New Secondary Metabolites from an Endophytic Fungus in Porodaedalea pini

Eight benzenoids including three new phenols, piniphenols A-C (1-3), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl) ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384. All structures were established by spectral analysis and comparison with the literature data. Of these isolates, 1 showed moderate NO inhibitory activity with an IC50 value of 60.0 mu M. Compound 1 also showed the androgen receptor (AR) antagonism with the IC50 value of 0.42 mu M. To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea.